小细胞肺癌168例治疗结果分析

Retrospective analysis of treatment of 168 patients with small cell lung cancer

目的 :探讨放射治疗在小细胞肺癌 (smallcelllungcancer ,SCLC)治疗中的作用。方法 :回顾性分析 168例SCLC患者的治疗 ,按治疗方式分为化放疗综合组和其他治疗组 ,比较不同治疗方式的疗效 ,分析放疗前后的局部控制率和死亡原因。结果 :化放综合治疗组的 1年、2年和 3年生存率分别是 70 %、2 2 2 %和 15 % ,其他治疗组的 1年生存率是 3 5 4%。化放综合组患者放疗后局部控制率有明显提高。局部控制的患者死亡原因多为脑转移 ,而局部未完全控制的患者死亡原因是脑转移和局部未控或复发。局部控制的患者比其他患者有较长的存活时间。结论 :放疗在SCLC的治疗中起重要作用 ,与化疗结合可提高局部控制率 ,进而提高生存率。

OBJECTIVE:To evaluate the roles of radiotherapy in the treatment of small cell lung cancer (SCLC). METHODS: From Jan.1980—Dec.1996,168 patients with SCLC were treated in our hospital,and 120 cases received the combined chemo-radiotherapy and 48 cases received other treatments including irregular chemotherapy,radiotherapy only and so on. The local control rates and 1-,2-,3-year survival rates were analysed.RESULTS: The survival rates of 1-,2-,3-year for the combined chemo-radiotherapy were 70%,22.2% and 15%, respectively. The survival rates of 1-,2-year for other treatments were 35.4% and 0. The local control was much better for the combined chemo-radiotherapy when radiotherapy was finished . The primary death cause was bain metastasis for completely local control,and the death causes were brain metastasis and /or locol uncontrol or recurrence for incompletely local control. CONCLUSIONS: Radiotherapy plays an important role in the treatment of SCLC. The combined chemo-radiotherapy can increase the local control rate and the survival rate.