新型血栓溶解剂P-6A类似物的合成研究

Synthesis of New P-6A Analogues with Potent Coronary Vasodilator Effect

报道在液相中用混合酸酐法合成了新型的 6个P 6A的五肽类似物 .通过定向分步递进 ,采用反应活性较高的混合酸酐合成法 ,以氯甲酸异丁酯作活化剂 ,以THF和DMF作溶剂 ,使每一步合成收率均高于 60 % .对所合成的 6个P 6A类似物进行了光学测定 ,元素分析和MS谱图分析确证 .

Six new P-6A analogues were synthesized in liquid phase using THF and DMF solvents, using an active reagent of isobutyl chloroformate and mixed anhydride method in every preparation step. The yield was more than 60% in every step of synthesizing peptides. Their structures were characterized by MS and elemental analysis. The examination of optical activities displayed that the first one was right rotation and the others kept left rotation to polarized light.