Cyfra21-1肿瘤标志物在头颈鳞癌诊断和预后评价中的作用

The diagnostic and prognostic significance on detection of Cyfra 21-1 in head and neck squamous cell carcinoma patients

Cyfra 21-1是近年来发现的一种细胞角蛋白19的可溶性片段,随着细胞发生癌变,癌细胞可以释放Cyfra21-1进入循环系统而被检测出来,因此越来越被广大临床医师所重视,包括头颈部外科医师也越来越重视Cyfra21-1在头颈部鳞状细胞癌中的临床应用价值。目前Cyfra 21-1被认为可作为判断头颈鳞癌患者预后的肿瘤标志物之一,但对头颈鳞癌的早期诊断价值尚存在争议。本文就Cyfra 21-1的特点以及在头颈部鳞状细胞癌中的临床应用新进展进行综述。

Cyfra 21-1, which was known as the soluble cytokeratin-19 fragment in recent years, could be detected in the serum after it was released into the circulatory system following carcinoma formation from normal epithelium cell. More and more doctors including the head and neck surgeons paid attention to the clinical application value on cancers such as head and neck squamous cell carcinoma. At present, Cyfra 21-1 is recognized as one of the tumor prognostic markers on head and neck squamous cell carcinoma; however, there is still debate about the early diagnostic value on head and neck squamous cell carcinoma. In this article, the characteristics of Cyfra 21-1 along with the recent clinical progress on head and neck squamous cell carcinoma were reviewed.