癌基因产物STAT5在乳腺组织中的表达及其临床意义

Expression of A Oncogenic Production Signal Transducers and Activator of Transcription 5(STAT5) in Normal Breastr and Breast Carcinoma Tissue and Their Clinical Significance

目的 :探讨信号传导与转录激活因子 5 (signaltransducersandactivatoroftranscription5 ,STAT5 )在乳腺良、恶性组织中的表达情况 ,分析STAT5的表达改变与乳腺癌发生、发展的关系。方法 :应用Westernblot检测 4 4例乳腺癌组织及其癌旁 5cm外正常乳腺组织中STAT5蛋白的表达。结果 :乳腺癌组织中STAT5蛋白表达水平明显高于正常组织 (P <0 .0 5 ) ,平均为正常组织的 1 .6 1倍 ;STAT5表达水平与乳腺癌分化程度及临床分期有关 (P <0 .0 5 ) ;STAT5表达水平与肿瘤大小、年龄无关 (P >0 .0 5 )。结论 :STAT5的过表达可能在乳腺癌的发生、发展过程中起重要作用。

Objective To investigatethe expression of a novel oncogenic production STAT5 in normal breast and breast carcinoma tissue. Methods Western blot analysis was performed on normal breast and cancerous tissueof 44 patients with breast carcinoma.Results The levels of STAT5 protein increase in breast carcinoma compared with adjacent normal tissue(P<0.05),the median value was in 1.61-fold increase,it was found that overespression of STAT5 was related to differntiation and malignant degree of tumor tissue(P<0.05).No sigllificant differences were found between STAT5 expression and such factors as tumor size,age. Conclusions Taken together,overexpression of STAT5 may play an important role in breast carcinogenesis and disease progression.