绝经期妇女长期小剂量激素替代治疗的观察研究

The research of long-time low-dose hormone replacement therapy in postmenopausal women

目的 观察激素替代治疗 (HRT)绝经妇女的子宫、卵巢和乳腺的声像图表现、绝经期症状及性激素的变化 ,评价长期小剂量HRT的临床价值。方法 82例长期HRT的绝经期妇女 ,其中服用尼尔雌醇(CEE3)38例、利维爱 (OrgOD14)23例、倍美力 (CE)21例 ,利用超声对其子宫、卵巢和乳腺进行观察 ,服药前及服药后每6个月检查1次 ,观察时间最短3年 ,最长10年 ,同时行Kupperman评分及性激素测定。结果HRT后子宫内膜厚度增加 ,治疗前后差异有显著性 ,治疗后平均子宫内膜厚度未超过5mm ,卵巢和乳腺未发现占位性病变 ,绝经期症状均显著改善。结论 绝经妇女长期小剂量HRT,具有副作用少、安全、有效、依从性高等优点 ,定期超声检查是一种很好的监测手段。

Objective To evaluate the clinical value of hormone replacement therapy(HRT)by observing uterus,ovary and breast of postˉmenopausal women with ultrasound. Methods 82postmenopausal women were divided into three groups:38cases in CEE3,23cases in OrgOD14,21cases in CE.We observed the uterus,ovary and breast of postmenopausal women before and after estrogen therapy per6months.Observing time lasts from3to10years,accompanying with Kupperman evaluation and sex hormone inspection. Results After HRT,the Endometrium became thick signifiˉcantly,average less than5mm.No masses in ovary and breast have been found,and the menopausal symptoms were improved significantly. Conclusion Long-term low-dose HRTis a safe,effective method and compliance with little side effect.It is a better way to inspect the women with ultrasound on schedule.