MNNG诱发大鼠胃癌前期肝中碱性磷酸酶、酸性磷酸酶同工酶变化的冰冻切片观察

ICE SECTIONS WATCHING ON THE CHANGS OF ALP ISOENZYME AND ACP ISOENZYME IN LIVER AT THE EARLY STAGE OF GASTRIC CANCER INDUCED BY MNNG

用冰冻切片技术对MNNG诱发Wistar大鼠胃癌前期肝中碱性磷酸酶 (ALP)、酸性磷酸酶 (ACP)的变化进行观察 .结果表明 :(1)ALP、ACP的定位在处理组与对照组间无明显变化 ;(2 )处理组比对照组ALP、ACP的活性增强 ;(3)处理组间比较 ,ALP、ACP的活性有上升趋势 .结果提示 ,在胃癌的诱发过程中ALP、ACP的含量的增加和活性的增强有利于细胞维持正常的生理功能 .ALP、ACP的含量和活性的变化有望成为肿瘤诊断、预后的辅助因子 。

By ice section cutting, the changes of ALP isoenzymes and ACP isoenzymes in liver at the early stage of gastric cancer induced by MNNG were measured. The results shows:① The settlements of ALP and ACP are not different between the handled groups and the bilingual groups. ② The activities of ALP and ACP in the handled groups are stronger than that of the bilingual groups. ③ The activities of ALP and ACP are increasing between the handled groups.The results suggested that the increasings of ALP and ACP are good to maintaining the normal physiological function.The changes of ALP and ACP are hoped to be a supplementary factor in the examination of gastric cancer and are very important to study.