2型糖尿病微量白蛋白尿相关危险因素分析

Analysis of correlative risk factors of microalbuminuria in patients with type 2 diabetes mellitus

目的 探讨 2型糖尿病患者的微量白蛋白尿相关危险因素。方法 对 6 5例 2型糖尿病合并微量白蛋白尿 (微量白蛋白尿组 )和 6 2例未合并微量白蛋白尿 (正常白蛋白尿组 )患者的微量尿白蛋白排泄率、病程、血压、空腹血糖、糖化血红蛋白、空腹胰岛素、体重指数及脂代谢指标进行比较与相关性分析。结果 ①微量白蛋白尿组患者的病程、血压、空腹血糖、糖化血红蛋白、甘油三酯、低密度脂蛋白、载脂蛋白B明显高于正常白蛋白尿组 ,高密度脂蛋白明显低于正常白蛋白尿组 ;②相关分析表明尿白蛋白排泄率与病程、血压、空腹血糖、糖化血红蛋白、甘油三酯、低密度脂蛋白、载脂蛋白B呈正相关 ;③逐步回归分析发现 ,尿白蛋白排泄率与病程、糖化血红蛋白、收缩压、甘油三酯呈正相关。结论 2型糖尿病患者的病程、血压、血糖、血脂是微量白蛋白尿的相关危险因素。

Objective To study the risk factors of microalbuminuria(MAU) in the patients with type 2 diabetes mellitus.Methods Urinary albumin excretion rate(UAER),disease course,blood pressure,fasting plasma glucose(FPC),HbA1c、 Fasting insulin(FINS)、 body mass index(BMI) and plasma lipids were examined in 65 patients with type 2 diabetes mellitus complicated with MAU and 62 patients with type 2 diabetes mellitus non-complicated with MAU.Correlation analysis was conducted.Results Disease course,blood pressure、FPC、HbAlc、TG,low density lipid(LDL) and ApoB were significantly higher in 65 cases but highdensity lipid(HDL)was lower than that of 62 cases with out MAV.Correlation analysis showed that UAER was positively correlative with disease course,blood pressure,FPG,HbA1c,TG,LDL-C,and ApoB.Stepwise regression analysis indicated that UAER was positively correlated with disease course,HbA1c,systolic blood pressure,and TG.Conclusion Disease course,blood pressure,blood glucose,and blood lipid are the correlated risk factors of MAU in type-2 diabetes mellitus.