摘要
报道一种从 (S) 苹果酰呀亚胺出发合成 β ,γ 二取代γ 内酯灵活方法 .该法可用于合成 ( 3R ,4S) blastmycinone ,反式 whisky内酯及相关天然内酯 .通过格氏加成引入γ 侧链使本法兼具多用性和灵活性 .
A flexible approach to γ-alkyl β-htdroxy γ-lactone is described. Tow of the lactones were converted into blastmycinone and trans-whisky lactone respectively. The method features a NaBH4 mediated reductive ring-opening of N,O-acetals, which is obtained via a regioselective Grignard reagent addition with (S)-N,O-dibenzylmalimide followed by lactoneization. The flexibility of the method allows the introduction of various γ-alkyl side chains by Grignard reagents addition.
出处
《化学学报》
SCIE
CAS
CSCD
北大核心
2004年第18期1794-1800,共7页
Acta Chimica Sinica
基金
国家自然科学基金 (Nos.2 0 2 72 0 4 8
2 0 390 0 50 5)
教育部科学技术研究重点项目资助课题