钙拮抗剂对重症急性胰腺炎肝损伤的保护作用

Protective effects of calcium antagonist on liver in severe acute pancreatitis

目的 探讨钙拮抗剂对重症急性胰腺炎 (SAP)肝损伤的作用。方法 Wistar大鼠 4 8只 ,随机分为假手术组、SAP组和钙拮抗剂治疗组。检测各组动物血中白细胞介素 1(IL 1)、白细胞介素 6 (IL 6 ) ,肿瘤坏死因子 α(TNF α)和丙二醛 (MDA)的含量 ,肝功能指标ALT、AST、LDH的变化 ,并观察肝脏和胰腺的病理变化。结果 钙拮抗剂能显著降低SAP大鼠血中IL 1、IL 6、TNF α和MDA的含量 (P <0 .0 5 ) ,肝功能指标 ,明显改善 (P <0 .0 5 ) ,肝脏和胰腺病理损害程度减轻。结论钙拮抗剂可抑制SAP大鼠某些炎性细胞因子及氧自由基的产生和释放 ,对肝脏损伤具有保护作用。

Objective To investigate the effect of antagonist on liver damage in severe acute pancreatitis(SAP). Methods Fourty-eight wistar rats were randomly divided into sham-operative, SPA and SAP with calcium antagonist therapy groups. The serum leels of IL-1, IL-6, TNF-α and MDA (malondialdehyde) were measured, and the changes of ALT, AST and LDH in serum were determined. Pathologic alteration of liver and pancrease was also observed. Results The serum levels of IL-1, IL-6, TNF-α and MDA in calcium antagonist therapy group were significantly lower than those in SAPgroup (P<0.05). Serum AST, ALT and LDH were significantly decreased (P<0.05). The pathologic damages score of the liver and pancreas. Conclusions During the course of SAP, calcium antagonist could reduce the levels of inflammatory mediators and oxygen free radical and has beneficial on liver damage.