肺心病患者血清甲状腺素含量变化及其临床意义

SERUM LEVELS OF THYROXINE IN PATIENTS WITH COR PULMONALE

目的 探讨 75例无甲状腺疾病的肺心病患者血清三碘甲状腺原氨酸 (T3 )、血清甲状腺素 (T4)和血清促甲状腺激素 (TSH)的含量变化及其关系。方法 检测 75例肺心病患者血清T3 、T4和TSH含量 ,另选 80例健康体检者作为正常对照组。结果 肺心病患者血清T3 降低 ,与正常对照组比较 ,P <0 .0 1,血清T4与正常对照组比较P >0 .0 5。有肺性脑病、消化道出血严重并发症时 ,低T3 血症尤为显著 ,P <0 .0 1。且多伴有低T4血症 ,P <0 .0 5。血清T4血症越低 ,病死率越高。结论 血清T3 、T4含量可作为判断肺心病轻重和预后指标之一。

Objective To investigate blood levels of T 3,T 4,TSH in cor pulmonale patients and the correlation among them. Methods Blood levels of T 3,T 4,TSH in 75 patients with cor pulmonale were detected,which were compared with those of normal 80 healthy adults in our laboratory. Results The blood levels of T 3 in cor pulmonale patients were significantly lower than those of controls(P<0.01). T 3 level was the lowest when companied with side effects such as pulmo-cerebral syndrome,gastrointestinal hemorrhage(P<0.01), and blood levels of T 4 were lower either(P<0.05). Conclusion Blood levels of T 3,T 4 may be clinical indexes for determining degree and prognosis of cor pulmonale patients.