神经元特异性烯醇化酶在急性一氧化碳中毒后迟发性脑病的变化及意义

Change and Significance of neuro specific enolase in patients with delayed encephalopathy after acute carbon monoxide poisoning

目的:探讨急性一氧化碳中毒后迟发性脑病(DEACMP)患者是否合并脑神经元的损伤。方法:45例DEACMP患者按病情轻重分为三组,应用酶联免疫分析法测定他们血清神经元特异性烯醇化酶(NSE)浓度并和20例对照组比较。应用单因素方差分析方法分析NSE浓度与病情严重程度以及预后的关系。结果:对照组血清NSE浓度为7.205±1.595μg/l。观察组血清和CSF NSE浓度分别为10.678±2.065μg/l、12.869±2.507μg/l、17.907±3.910μg/l。观察组和对照组之间存在统计学差异(P<0.05)。结论:DEACMP患者血清NSE浓度明显增高,NSE浓度的高低不仅可作为脑神经元损伤的量化指标,而且也是判断病情、估计预后的重要参数。

Objective: To explore neuronal damage in patients with delayed encephalopathy after acute carbon monoxide poisoning (DEACMP). Methods: The serum neuron-specific enolase(NSE) levels were determined by ELISA from 45 patients with delayed encephalopathy after acute carbon monoxide poisoning and 20 controls. The relations were analyzed among NSE levels and the extent of the neurologic damage and prognosis. Results: The concentrations of serum NSE Were 7. 205±1. 595μg/l in the controls. The concentrations of serum NSE were 10. 678±2. 065μg/l 12. 869±2. 507μg/l 17. 907±3. 910μg/l respectively in the patients with DEACMP. The difference of NSE levels was significant between the controls and the cases with DEACMP(P<0. 01). Conclusions: The levels of hte serum NSE and CSF NSE remarkably increase in the patients with DEACMP. The alternation of NSE not only provides quantitative information about the degree of certain neurologic lesions, but also possibly serves as an important parameter of assessing the prognosis.