药物性肝炎136例分析

An Analysis of Clinical Features of 136 Patients with Drug Hepatitis

目的 :分析 136例药物性肝炎的病因和临床特点 ,以加深对药物性肝炎的认识。方法 :根据服药史、临床表现、肝功能、血清标志及停药后的治疗效果综合判断。结果 :引起肝损害的药物多见于中草药 ,特别是治疗皮肤病和风湿骨关节病、肾炎等疾病的中草药 (2 8.6 8% ) ,抗结核药物 (2 7.2 1% ) ,抗甲状腺药物 (10 .2 9% )和抗感染药物 (5 .88% )等。大多数药物性肝炎出现于服药后 1～ 2月。HBSAg阳性者更易发生药物性肝炎及重症肝炎。结论 :影响药物性肝炎的因素有药物种类、用药时间、联合用药、患者自身健康状况等。

Objective: To enhance the understanding of drug hepatitis by analyzing the etiology and clinical features of 136 cases with drug-induced liver disease.Method: 136 cases with drug-induced liver damage admitted to our hospital from 19992004 were reviewed according to their drug histories, clinical features, liver function tests and serum markers and responses to withdrawal.Result: The etiological drugs were herbal medicine (a(c)28.68%), anti-tuberculosis drugs (a(c)27.21%aa), antia2thyroid agent (a(c)10.29%aa), and anti-infectious drugs (a(c)5.88%), and also included antia2tumor agents (a(c)3.60%), anti-psychotic drugs (a(c)3.60%), and so on. Most of the drug hepatitis appeared during the first month to the second month of the treatment. Patients with HBSAg positive were at a higher risk of drug hepatitis,even severe hepatitis.Conclusion: Conclusion The factors to influence drug hepatitis include the kinds of drugs to be used,duration of drugs used,combined use of drugs,health condition,etc.