眼附属器MALT型淋巴瘤Ki-67和p53表达与胃肠MALT型淋巴瘤比较

Ki-67 and p53 expression in ocular adnexal MALT-type lymphoma and to compare with those in gastrointestinal tract MALT-type lymphomas

目的 研究眼附属器MALT型淋巴瘤Ki 6 7和 p5 3表达对临床治疗的选择和预后评估的意义。方法 采用免疫组化的方法 ,检测 2 9例眼附属器MALT型淋巴瘤Ki 6 7和p5 3表达 ,分析其在不同临床特征间的差异 ;并与 15例胃肠MALT型淋巴瘤的Ki 6 7和 p5 3表达进行对比。 结果 2 9例眼附属器MALT型淋巴瘤在不同年龄、性别、发病部位Ki 6 7和 p5 3表达差异无显著性 (P >0 .0 5 )。在分期上 ,2例非Ⅰ期病例出现Ki 6 7的高表达。与胃肠MALT淋巴瘤对比 ,2 9例眼附属器MALT型淋巴瘤未见有高恶转化 ,p5 3表达程度低 ;15例胃肠MALT淋巴瘤有 5例出现高恶转化 ,其中 3例p5 3出现高表达 ,差异有显著性 (P <0 .0 5 )。结论 Ki 6 7和 p5 3的高表达对眼附属器MALT型淋巴瘤的临床分期和高恶转化有一定的提示作用 ;与胃肠MALT型淋巴瘤相比 ,Ki 6 7和p5 3表达率、表达程度低 ,提示预后较好。

Objective To study the role of the expression o f Ki-67 and p53 gene protein in ocular adnexal MALT-type lymphoma in the clini cal treatment and prognosis. Methods Twenty-nine cases of ocular adnexal MALT-type and 15 cases of gastrointestinal MALT-typ e lymphoma were studied. The immunohistochemistry studies were performed using p 53 tumor expression gene and Ki-67 nuclear proliferative factor to study the tu mor cell.The expression of p53 and Ki-67 in adnexal MALT-type lymphoma was co mpared with that in gastrointestinal MALT-type lymphoma. Results In 29 cases of ocular adnexal MALT-type,the express ion of Ki-67 and p53 gene protein did not correlate with age,sex and location ( P>0.05).Two cases in Ⅱ and Ⅳ clinical stage strongly expressed Ki-67 gene protein.There was no high-grade transformed lymphoma.But in 15 cases of the ga strointestinal tract MALT-type lymphomas,5 cases were high-grade transformed l ymphoma.And in these 5 cases, 3 cases' strength of p53 gene protein posit ivity were significantly different with those in ocular adnexal MALT-type lymphoma (P<0.05). Conclusion The high expression of Ki-67 and p53 has great valu es in the diagnosis of ocular adnexal MALT-type lymphoma,grades of histology a nd clinical stage;and plays an important role in the prognosis of the ocular adn exal MALT-type lymphoma.