原发性高血压患者α- Adducin基因单核苷酸多态性(Gly460Trp)与血清胆红素含量相关性(英文)

Significant Associations of the α-Adducin Gene Gly460Trp Polymorphism with Serum Bilirubin Concentrations in Chinese Essential Hypertension Patients

探讨了自 2 0 0 0年 9月到 2 0 0 1年 1月来自安徽省霍邱县地区原发性高血压人群中α Adducin基因单核苷酸多态性与血清中总胆红素、直接胆红素和间接胆红素含量的相关性。在原发性高血压女性患者中 ,在校正了许多可能影响胆红素含量的重要因素后 ,与携带有Gly4 6 0Gly基因型的高血压女性患者相比较 ,携带有Trp4 6 0Trp基因型的高血压女性患者血清平均总胆红素 (β =- 1 2 μmol/L ;P =0 0 1)、直接胆红素 (β =- 0 4 μmol/L ;P =0 0 2 )和间接胆红素 (β=- 0 8μmol/L ;P =0 0 3)的含量比较低。在女性中抽取总胆红素、直接胆红素和间接胆红素含量最高和最低的各 2 5 % ,在校正了重要的变量后发现携带Trp/Trp基因型的女性比Gly4 6 0Gly基因型的女性有更大的可能性血清总胆红素含量 (OR值 =4 0 ;95 %可信区间 :1 6～ 10 2 ;P <0 0 1)、直接胆红素含量 (OR值 =4 0 ;95 %可信区间 :1 6～ 9 7;P <0 0 1)和间接胆红素含量 (OR值 =2 7;95 %可信区间 :1 1～ 6 7;P =0 0 3)更低。然而 ,在男性高血压患者中没有发现任何明显的相关性。以上的结果认为在中国原发性高血压女性患者中 ,Trp/Trp基因型与低的血清胆红素含量有直接关系 ,因为Trp/Trp基因型的女性的低血清胆红素 。

We investigated associations of the Gly460Trp polymorphism of the α-adducin gene and concentrations of serum total bilirubin,serum direct bilirubin and serum unconjugated bilirubin in patients with essential hypertension from Anhui,China from September 2000 to January 2001.Compared to women with the Gly/Gly genotype and after adjustment for important covariates,women with the Trp/Trp genotype had lower mean concentrations of serum total bilirubin (β=-1.2 μmol/L; P =0.01),serum direct bilirubin (β=-0.4 μmol/L; P =0.02) and serum unconjugated bilirubin (β=-0.8 μmol/L; P =0.03).Among women in either the upper or lower quartiles of serum total bilirubin,serum direct bilirubin and serum unconjugated bilirubin and compared to those with the Gly/Gly genotype,women with the Trp/Trp genotype had higher odds of being in the lower quartile of concentrations of serum total bilirubin (odds ratio=4.0; 95 percent confidence interval:1.6～10.2; P <0.01),serum direct bilirubin (odds ratio=4.0;95 percent confidence: 1.6～9.7; P <0.01) and serum unconjugated bilirubin (odds ratio=2.7; 95 percent confidence interval: 1.1～6.7; P =0.03) after adjustment for important covariates.We did not observe any significant associations in these models for men.We concluded that the Trp/Trp genotype of α-adducin Gly460Trp was associated with lower serum bilirubin concentrations in this group of Chinese women with essential hypertension.Women with the Trp/Trp genotype of α-adducin Gly460Trp might have increased risk for cardiovascular diseases due to lower concentrations of serum bilirubin.