摘要
本文通过在α-糖苷酶水解麦芽糖的体系中加入一定量的中药提取物,并采用葡萄糖氧化酶法测定葡萄糖的释放量,建立了一个中药中α-糖苷酶抑制剂的筛选模型.应用该模型对糖尿病治疗中药的筛选结果表明,桑白皮、桑枝以及桑叶等十种中药被证实有α-糖苷酶的抑制剂活性,可以有效地抑制或延缓淀粉和麦芽糖水解为葡萄糖,揭示了中药降糖的另一种机理,并为开发安全有效的糖尿病治疗中药提供了新的思路.
In this paper, the sensitive screening model of α-glucosidase inhibitor was established. The results showed that Cortex Mori, Ramulus Mori and Folium Mori among ten traditional Chinese medicine (TCM) extracts had strongly α-glucosidase inhibition in hydrolysis processes of starch or maltose. Therefore , TCM extracts might cure diabetes. The present researches remain to be developed the new natural medicines for safe and effective diabetic therapy.
出处
《南开大学学报（自然科学版）》
CAS
CSCD
北大核心
2004年第3期98-102,共5页
Acta Scientiarum Naturalium Universitatis Nankaiensis
基金
SupportedbyScienceFoundationofTianjin(023803811)863ProjectofModernizationofTraditionalChineseMedicine
关键词
α—糖苷酶抑制剂
糖尿病
中药
桑白皮
桑枝
桑叶
α-glucosidase inhibitor
diabetes
traditional Chinese medicines 5 Cortex Mori
Ramulus Mori
Folium Mori
