奥扎格雷钠与阿斯匹林合用对不稳定型心绞痛患者血液流变学影响

Effects of Ozagrel and Aspirin on Hemorheology in Patients with Unstable Angina Pectoris.

目的 观察奥扎格雷钠与阿斯匹林合用对不稳定型心绞痛 (UAP)患者血液流变学影响。方法 随机将收治的 4 2例UAP患者分为对照组 2 1例和治疗组 2 1例 ,对照组给予口服阿斯匹林片等常规治疗 ;治疗组则在常规治疗基础上 ,每天用奥扎格雷钠 16 0mg溶于 5 0 0ml生理盐水中静滴 ,连用 2周 ,监测治疗前后血液流变学参数、心电图和心绞痛症状等。结果 治疗组在心绞痛缓解和消失时间等方面优于对照组 (P均 <0 0 1)。治疗组治疗后纤维蛋白原含量、血细胞比容、血小板聚集率均较治疗前显著降低 (P <0 0 1～ 0 0 5 ) ,全血比黏度较治疗前有所降低 ,但无统计学意义 (P >0 0 5 ) ;对照组治疗后血小板聚集率较治疗前显著降低 (P<0 0 5 ) ,其余各指标差异无统计学意义 (P <0 0 5 ) ;两组用药过程中均无出血并发症。结论 在常规治疗基础上加用奥扎格雷钠能显著降低血小板聚集率等血液流变学参数 ,更有效治疗UAP。

Objective To observe the effect of ozagrel and a spirin on hemorhelolgy in patients with unstable angina pectoris(UAP). M ethods A total of 42 patients with UAP were randomly divided two groups. patients in one group were received treatment lincl uding aspirin 100mg/d as control group. into and patients in another group were receivied aspirin 100mg/d plu s ozagrel 160mg/d(research group)for 2 weeks. The parametes of hemorheology,ECG ST-T and UAP symptoms were measured. Results The remission of UA P symptoms was significantly improved in research group than that in control gr oup(P<0.01).The fibrinogen, hematocrit and platelet aggregation rate were significantly decreased after treatment in research group (P<0.01～0.0 5). Only platelet aggregation rate was significantly decreased after treatment in control group (P<0.05). Both group had no bleeding divring treatment. Concl usions Treatment with aspirin plus ozagrel is more efficient than aspiri n alone during the acute stage of UAP.[