碱性成纤维细胞生长因子在人成釉细胞瘤中的表达及意义

Expression of basic fibroblast growth factor in human amelobla stoma

目的 :研究碱性成纤维细胞生长因子 (bFGF)在成釉细胞瘤 (AB)中的表达及意义。方法 :采用免疫组织化学S P法 ,检测 4例正常口腔黏膜 ,11例牙源性角化囊肿 (OKC) ,6 1例AB中bFGF的定位表达。结果 :bFGF在AB中的表达明显高于OKC及正常口腔黏膜 (P <0 .0 5 ) ,在AB原发、复发、恶变的不同病变中 ,bFGF的表达强度逐渐增加 (P <0 .0 5 )。结论 :AB侵袭性生物学行为与bFGF的高表达密切相关 ,bFGF可能为AB血管生成的主要因子之一。

Objective: To study the expression of basic fibroblast gr owth factor (bFGF) in human ameloblastoma (AB) Methods: Expr ession of bFGF was detected in 61 cases of AB (including 36 cases of primary AB, 19 of recurrent AB, 6 of malignant AB), 11 cases of odontogenic kera tocyst (OKC), and 4 cases of oral normal mucosa. Standard immun- ohistochemical techniques were used. Results: The expres sion of bFGF in AB was higher than that in OKC and normal oral mucosa, a nd significant difference was shown (P<0.05). The expression rate of bFGF in creased gradually in primary, recurrent, and malignant AB (P<0.05). The posi tive staining were mainly found in cytoplasm, and partly in the nuclei of cells. Conclusion: Tumor invasive biological characteristics in AB a re closely related to the expression of bFGF, and bFGF may be an important facto r in angiogenesis.