急性病毒性脑炎患儿血清中VEGF和IL-6水平的研究

Levels of vascular endothelial growth factor and IL-6 in serum of children with acute viral encephalitis

目的 :探讨血管内皮生长因子 (VEGF)在急性病毒性脑炎 (VE)发病机制中的作用及与白细胞介素 (IL 6 )的关系。方法 :应用ELISA法检测 4 2例VE患儿血清VEGF和IL 6水平 ,30例同年龄组非感染性神经系统疾病患儿做对照。结果 :IL 6水平在VE的急性期与恢复期均比对照组明显升高 ,而且急性期IL 6水平也明显高于恢复期。有频繁抽搐、昏迷及脑干症状的重度患儿血清IL 6水平明显高于轻度患儿 ;VE的急性期和恢复期VEGF水平均较对照组升高 ,但 3组比较无统计学意义。结论 :IL 6可能参与VE的发病 ,高水平的血清IL 6对VE的诊断、临床严重性的评估有参考价值 ;VEGF水平增加 ,在病脑发病中的作用需进一步探讨。

Objective: To assess the role of vascular en dothelial growth factor(VEGF) and the relationships between VEGF and IL-6 in th e pathogenesis of acute viral encephalitis (VE). Methods:We m easured IL-6 and VEGF levels in serum samples from 42 patients with acute viral encephalitis by ELISA. The results were compared with 30 age-matched controls w ith noninfectious neurologic diseases. Results:The levels of IL-6 were eminently elevated in acute phase and recovery phase of patients with acute VE compared with the control group. The level of IL-6 in acute phase of acute VE was higher than that in the recovery phase. The serum level of IL-6 wa s also higher in severe group than that in mild group. The level of VEGF was ele vated in acute phase and the recovery phase of the patients with acute VE. Howev er, the serum VEGF levels of various groups were not statistically different. Conclusion:IL-6 may mediate acute VE and the high serum concen tration of IL-6 could be an indicator for diagnosis and judging the severity of acute viral encephalitis. The level of VEGF did not increase significantly. Whe ther VEGF may play a role in the pathophysiology of acute VE or not the process remains to be determined.