摘要
根据合理药物设计原理,设计合成了4个环维黄杨星D衍生物,进行了抗心律失常及蛙心正性肌力药理实验,结果表明其药理效果优于环维黄杨星D。
According to rational drug design principle, a series of cyclovirobuxine D analogues were prepared, and their bioactivities were tested.Four new compounds were obtained and confirmed by spectrums.Antiarrhythmia effects and positive inotropic effects of some analogues of cyclovirobuxine D were tested. Some compounds showed better activity than that of cyclovirobuxine D.
出处
《化学研究与应用》
CAS
CSCD
北大核心
2004年第5期623-625,共3页
Chemical Research and Application
关键词
环维黄杨星D
衍生物
抗心律失常
正性肌力
cyclovirobuxine D
derivatives
antiarrhythmia effects
positive inotropic effects
