^(99)Tc^m-MIBI肿瘤显像对肺结节的诊断价值

The value of^(99) Tc^m-MIBI lung imaging for the diagnosis of lung neoplasms

目的 探讨^(99)Tc^m-甲氧基异丁基异腈(MIBI)肺肿瘤显像对肺癌的诊断价值。方法对12例正常对照组、28例肺良性结节、44例肺癌患者行^(99)Tc^m-MIBI肺肿瘤显像,结合影像学表现和半定量指标早期相摄取比值(ER)、延迟相摄取比值(DR)对结节性质进行判断。结果 对照组ER=1.02±0.10,DR=1.01±0.10;肺良性结节组ER=1.15±0.13,DR=1.14±0.13;肺癌组ER=1.51±0.26,DR=1.43±0.21。以ER≥1.28为阳性显像,诊断肺癌的灵敏度为88.6％,特异性85.7％,准确性87.5％;以DR≥1.27为阳性显像,诊断肺癌的灵敏度为84.1％,特异性92.9％,准确性87.5％。结论 ^(99)Tc^m-MIBI肺肿瘤显像对肺良恶性结节的鉴别诊断具较大实用价值。

Objective To investigate the method of 99Tcm-methoxyisobutylisonitrile (MIBI) lung imaging and its value for the diagnosis of lung neoplasms. Methods 99Tcm-MIBI lung imaging was performed on 44 cases with lung neoplasms, 28 with benign lesions, and 12 normal controls. The characters of the nodules were defined by the images and the semiquaiititative measurements of the early T/N ratio (ER) and delayed T/N ratio (DR). Results The value of ER in control, benign and malignant group was 1.02 ± 0.10, 1.15±0.13, 1.51±0.26, respectively. The value of DR in these three groups was 1.01 ± 0.10, 1.14± 0.13, 1.43 ±0.21, respectively. While ER≥1.28, or DR≥1.27 were defined as positive, the sensitivity was 88.6% and 84.1%, the specificity 85.7% and 92.9% , the accuracy 87.5% and 87.5% , respectively. Conclusion 99Tcm-MIBI lung imaging is very useful for differentiating benign and malignant pulmonary nodules.