涂碳型PVC膜依诺沙星选择电极的研制与应用

Preparation and application of a coated carbon PVC membrane enoxacine electrode

目的 建立盐酸依诺沙星药片的测定方法。方法 以依诺沙星与溴汞酸盐生成缔合物为电活性物 ,制作涂碳PVC膜依诺沙星电极。结果 在 pH 1.5～ 4 .5内 ,电极的Nernst响应范围为 1.0× 10 -2 ～ 5 .0× 10 -5mol/L ,斜率为 31.0mV/ pC ,检测限为 4 .2× 10 -6mol/L。平均回收值为 98.0 % ,RSD为 1.0 %。结论 用于该药片的含量测定 。

OBJECTIVE To determine contents of enoxacine hydrochloride. METHOD A coated carbon PVC membrant enoxacine selective electrode based on enoxacine and mercuric bromide was prepared.RESULTS The electrode showed Nernst response for enoxacine with a slope of 31.0 mV/ pC over the concentration range of 1.0×10 -2 ～5.0×10 -5 mol/L and detection limit of 4.2×10 -6 mol/L. The average recovery was 98.0%, and RSD for 2.0%( n =9).CONCLUSION The results obtained agree with those of ultraviolet spectrophotometry.