摘要
RNA干涉是通过双链RNA的介导特异性地降解相应序列的mRNA,从而导致转录后水平的基因沉默,这一过程在拟南芥、线虫和真菌等多种模式植物中发现。RNAi是研究多种生物基因功能的有效手段,本文综述了RNA干涉的分子机理及其应用研究进展。
RNA interference degrades mRNA specifically and potently though the mediation of corresponding double-stranded RNA and leads to post-transcriptional gene silencing .RNAi was observed in many model organisms such as Arabidopsis thaliana,Caenorhabditis elegans and fungi. It is a useful way for studying gene function. Here the mechanism and application of RNAi are reviewed.
出处
《激光生物学报》
CAS
CSCD
2003年第6期460-462,共3页
Acta Laser Biology Sinica
基金
863项目"玉米对生性状的分子标记辅助选择育种技术研究"(2002AA211071)
关键词
RNA干涉
双链RNA
基因沉默
RNA interference
double-stranded RNA
gene silencing
