梗阻性黄疸患者红细胞免疫功能检测及分析

Measurement and Analysis of Red Blood Cell Immune Function in Patients with Obstructive Jaundice

目的 研究梗阻性黄疸患者手术前后红细胞免疫功能状况。方法 对 2 1例梗阻性黄疸患者 ,分别于手术前 1d、手术后 1、5、10d测定红细胞C3b受体花环 (RCR)及红细胞免疫复合物花环 (RICR) ,并与 10例健康献血者作为正常对照组比较。结果 梗阻性黄疸时患者红细胞免疫功能受到抑制 ,RCR和RICR与正常对照组相比均有显著性差异 (P <0 .0 5 ) ;手术创伤可使梗阻性黄疸患者红细胞免疫功能进一步降低 ,手术前 1d与手术后 1d相比 ,RCR有显著性差异 (P <0 .0 5 ) ,而RICR虽有一定升高但无显著性差异 (P >0 .0 5 )。手术后第 5d与手术前 1d相比 ,RCR和RICR均无显著性差异 (P >0 .0 5 ) ,患者红细胞免疫功能逐渐恢复 ,达到或接近术前水平。手术后 10d与手术前 1d相比 ,RCR升高而RICR降低且均有显著性差异 (P <0 .0 5 ) ,但RCR仍明显低于正常对照组 (P <0 .0 5 ) ,而RICR则接近于正常对照组 (P >0 .0 5 )。结论 梗阻性黄疸患者存在着红细胞免疫功能抑制 ,手术创伤可使其下降 ,解除梗阻。

Objective To research the immune function of red blood cell in patients with obstructive jaundice.Methods Twenty one patients with obstructive jaundice were chosen as subjects, RCR and RICR were measured on the day before operation and the 1st,5th,10th postoperative days, and ten normal volunteers were chosen as normal contrast. Results The immune function of red blood cell in patients with obstructive jaundice was depressed. RCR and RICR were significantly different in comparison with those in the normal group ( P <0.05); The surgical operation wound can make the immune function of red blood cell further lower, RCR on the day before operation was significantly lower than that on the 1st postoperative day ( P <0.05), but no significant changes were seen in RICR levels ( P >0.05). RCR and RICR on the 5th postoperative day have no significant changes in comparison with those on the day before operation ( P >0.05). The immune function of red blood cell gradually recovers or near to the level of the day before operation. To the 10th postoperative day, RCR increased obviously and RICR decreased significantly ( P < 0.05 ), but compared with the normal group,RCR was lower yet ( P <0.05), and RICR was near to the level of normal group ( P >0.05). Conclusion The red cell immune function of patients with obstructive jaundice was inhibited, and the operation can make the immune function of red blood cell further lower. Drainage and removing obstruction can make red cell immune function partly recover.