习惯性流产夫妇的染色体异常分析

Analysis of Chromosome Abnormalities in Recurrent Abortion

目的探讨习惯性流产与染色体异常的关系。方法对早期有习惯性自然流产史的154对夫妇进行外周血染色体核型分析。结果154对夫妇中有24例染色体核型异常,异常检出率为15.58％。其中平衡易位15例,臂间倒位3例,Y染色体变异5例,常染色体变异1例,均出现2次以上早期自然流产。结论习惯性流产夫妇任何一方的染色体异常均可引起流产等不良妊娠,9号染色体倒位和染色体变异与早期自然流产关系密切。

Objective To investigate the relationship between recurrent abortion and chromosome abnormality. Methods Chromosome karyotypes for the 154 couples with the history of recurrent abortion were analysed. Results Abnormal chromosome karyotypes were found in 24 cases of all the 154 couples accounting for 15.58% of the total. Among the abnormalities, 15 cases were balanced transloca-tion, 3 cases were inversion between arms, 5 case were Y chromosome mutation and 1 case was somatic chromosome mutation. Conclusion Disfavorable pregnancy such as abortion may result from chromosome aberration in any side of the couple with recurrent abortion. The 9th chromosome inversion and Y chromosome variation are closely related to the early recurrent adortion.