2型糖尿病伴感染患者细胞免疫和体液免疫的研究

The Study of Cell Immunity and Humoral Immunity in Type 2 Diabetic Mellitus Patients Complicating With Infections

目的 :探讨 2型糖尿病伴感染患者血液中细胞免疫和体液免疫的变化。方法 :采用流式细胞术和速率散射免疫比浊法测定 2 2例糖尿病伴感染患者血液细胞免疫参数 (CD3、CD4、CD4/CD8、B细胞、NK细胞 )和血清免疫球蛋白 (IgG、IgA、IgM )、补体 (C3、C4)等体液免疫参数 ,并与 40例 2型糖尿病不伴感染患者及 46例健康体检者比较。结果 :2型糖尿病无论是否伴有感染 ,与健康对照组比较 ,CD4、CD4/CD8、B细胞、NK细胞显著性减低 (P <0 .0 1) ,IgA、IgM、C3显著升高 (P <0 .0 1) ;伴感染组与不伴感染组比较 ,CD3、CD4/CD8、B细胞、NK细胞及C3、C4均显著增高。结论 :2型糖尿病患者无论是否伴有感染 ,机体内细胞免疫和体液免疫功能均已减低 。

Objective To investigate the change s of cell immunity and fluid immunity in type 2 diabetic mellitus patients complic ating with infections. Methods We have analyzed T cell sub sets(CD3?CD4?CD8),CD4 /CD8,B-cells,nature killer cells (NK) and immunoglobu lins (IgG?IgIgM),complements(C3?C4) in 22 diabetic mellitus patients compli cating with infections, compared with those of 40 diabetic mellitus patients wit hout infections, and 46 normal controls. Results Type 2 di abetic mellitus patients with and without infections,CD4,CD4/CD8,B,NK are signif icantly lower and IgA,IgM,C3,C4 significantly higher than those of normal contro ls (p<0.01);meanwhile, CD3,B,NK,C3,C4 in type 2 diabetic mellitus patients with infections are significantly higher than those of type 2 diabetic mellitus patie nts without infections. Conclusion These results indicated that there were impaired immune function in type 2 diabetic mellitus patients w ith and without infections ; after infections,T cell subsets,B-cells,nature ki ller cells (NK) and immunoglobulins were increased.