转录因子E2F-1在肺癌组织中表达的意义

Significance of Transcription Factor E2F-1 Expression in Lung Carcinoma

目的 :探讨转录因子E2F 1在肺癌发病机制中的作用及其与肿瘤生物学行为之间的关系。方法 :应用免疫组化方法检测E2F 1在 4 6例肺癌和 8例正常肺组织中的表达。结果 :在肺癌组织中E2F 1阳性率为 5 8 7% ,显著高于正常肺组织的 12 5 %。E2F 1表达随肿瘤分期升高而增高 ,不同病理类型肺癌组织的E2F 1表达也有差异 ,但与淋巴结转移无相关。结论 :E2F 1异常高表达在肺癌发生发展过程中起重要作用 。

Objecitve To investigate the role of transcription factor E2F-1 in pathogenesis of lung carcinoma and its relationships with tumor biological behaviors.Methods Immunohistochemical method was adopted to examine expressions of E2F-1 in 46 cases of lung carcinoma and 8 cases of normal lung tissues.Results Positive rate of E2F-1 immunostaining in lung carcinoma was 58.7%,which was significantly higher than 12.5% in normal lung tissues.Expression of E2F-1 was closely associated with tumor stage and pathological types,but had no relation to tumor lymph node metastasis.Conclusions The aberrant expression of E2F-1 may play an important role in the development and progression of lung carcinoma,and can be used to predict tumor invasiveness.