夏天无总生物碱的身体依赖性实验研究

Studies on the Physical Dependence of Xiatianwu Total Alkaloid in Mice

采用小鼠跳跃反应及竖尾反应试验评价夏天无总生物碱的身体依赖性 ,观察夏天无总生物碱的身体依赖性。结果表明 ,在小鼠跳跃反应试验中 ,小鼠 ig夏天无总生物碱 4 0 ,9,2 m g/ (kg/ d) ,连续 14天 ,再 ip纳洛酮 ,均未出现跳跃反应 ,且体重下降百分率与对照组相比 ,亦无显著性差异 (P>0 .0 5 ) ;在竖尾反应试验中 ,小鼠 ig夏天无总生物碱 2 0 ,4 0 ,80 mg/ kg均未出现 S形竖尾反应。

To observe the physical dependence of Xiatianwu total alkaloid,the test of jumping response and Straub's tail reaction were used to evaluate the physical dependence of Xiatianwu total alkaloid.In the test of jumping response in mice, the mice received Xiatianwu total alkaloid 40,9,2mg/(kg·d)(ig) for 14 d, followed by ip naloxone, there were no jumping responses and no significant differences (P>0.05) in the percentage of body weight loss, compared with the control group. In mice, ig Xiatianwu total alkaloid 20, 40,80mg/kg, there were no Srtaub's tail reaction and motot activity, Conclusion: These results indicate that Xiatianwu total alkaloid has no physical dependence in mice.