摘要
目的评价口服5-氨基水杨酸(5-ASA)壳聚糖胶囊后在大鼠体内的吸收与在结肠组织中的分布规律.方法在轻度乙醚麻醉下通过聚乙烯管给大鼠口服5-ASA壳聚糖胶囊3粒(1.6mg/粒),对照组口服5-ASA羧甲基纤维素混悬液1 ml(4.8mg).于给定的时间间隔从大鼠心脏取血,并取出结肠组织.用HPLC法测定大鼠血液及结肠中药物的浓度.结果壳聚糖胶囊组血清中的时间-浓度曲线下面积(AUC0～12)是对照组AUC0～12的0.62倍;而结肠组织中壳聚糖胶囊组AUC～12是对照组AUC0～12的3.62倍.结论5-ASA壳聚糖胶囊具有较好的结肠定位靶向释药特性.
Objective To examine the absorption and distribution of 5-am in osalicylic acid (5-ASA) in rat colon after oral administration of its chitosan capsule. Methods5-ASA in chitosan capsules (4.8 mg per 3 capsules) were adminis tered orally in rats via a polyethylene cannula under light ether anest hesia. The rats in control group were given 1 ml 5-ASA carboxymethyl ce llulose suspension (4.8 mg). Blood samples were obtained from the rat hearts and the colon tissues sampled at a given interval to measure the concentration of 5-ASA by HPLC. Results The area under the curve (AUC 0-12 ) in the serum samples of chitosan capsule group was 0.62 times that of the control group, while in the colon tissue, the AUC 0-12 of chitosan capsule group was as much as 3.62 times that of the control gr oup. Conclusions The chitosan capsule may be a useful carrier of 5-ASA for colo n-specific delivery.
出处
《第一军医大学学报》
CSCD
北大核心
2003年第5期431-434,共4页
Journal of First Military Medical University
基金
归国笹川生启动基金(055)
广东省自然科学基金(020056)
广东省医学科研基金(A2002371)~~
关键词
5-氨基水杨酸
结肠定位
吸收
分布
壳聚糖
aminosalicylic acid
colon-specific delivery
ab sorption
distribution
chitosan
