谷胱甘肽S-转移酶M1基因缺失与子宫内膜异位症易感性的关系

Association between glutathione S-transferase M 1 gene deletion and genetic susceptibility to endometriosis

目的探讨谷胱甘肽S-转移酶M1(GSTM1)基因遗传缺失与子宫内膜异位症(内异症)易感性的关系.方法采用PCR技术对76例经腹腔镜或手术证实为内异症的患者(内异症组)和80例非内异症的妇科手术患者(对照组)的GSTM1基因型进行检测.两组均为广东籍汉族妇女.结果GSTM1空白基因型频率在内异症组和对照组中分别为65.8%和46.3%,差异具有显著性(x2=6.03,P=0.014).GSTM1空白基因型的个体患内异症的风险是GSTM1非空白基因型个体的2.24倍(OR=2.24,95%CI=1.17～4.27).结论GSTM1基因缺失可能是广东汉族妇女内异症发病的危险性因素之一.

Objective To evaluate the possible association of the glutathion e S-transferase M1 (GSTM1) gene polymorphism with the susceptibility to endometri osis in women of Han nationality in Guangdong Province. Methods Polymerase chain reaction was used to identify the GSTM1 genotypes in 76 patients with endometr iosis and 80 controls (surgical patients for gynecological problems other than endometriosis). Results The frequencies of the GSTM1 null genotypes in patients with endometriosis and controls were 65.8% and 46.3%, respectively, showing a s ignificant difference between the endometriotic cohort and the control grou p ( 2 =6.03, P<0.05). Individuals with GSTM1 null genotype were exposed t o risks for endometriosis 2.24 times that of subjects without these genotypes (OR=2.24, 95% CI=1.17-4.27).Conclusion GSTM1 gene deletion might bea risk fac tor for endometriosis in women of Han nationality who are native residents in Gu angdong Province.