胰岛素样生长因子及其结合蛋白在儿童白血病中的动态变化
摘要
胰岛素样生长因子 (IGFs)在儿童急性白血病治疗过程中会出现相应改变 ,IGFs具有促生长作用 ,体外试验证实对白血病细胞系有剂量相关的促增殖效应。同时 ,具有生物活性的游离IGF I水平始终增高 ,IGFs在儿童白血病的发生、发展中起重要作用 ,其结合蛋白在血清和脑脊液中也会出现不同的变化 ,可作为疾病复发和中枢神经系统白血病的监测指标之一。
出处
《国外医学（儿科学分册）》
2003年第6期302-304,共3页
Foreign Medical Sciences（Section of Pediatrics)
参考文献13
-
1Arguelles B, Barrios V, Pozo J, et al. Modifications of growth velocity and the insulin-like growth factor system in children with acute lymphoblastic leukemia: a longitudinal study[ J]. J Clin Endocrinol Metab,2000, 85(11) :4087-92.
-
2Hasegawa T, Hasegawa Y,Takada M, et al. The free form of insulin-like growth factor I increase in circulation during normal human pregnancy[J].J Clin Endocrinol Metab, 1995,80( 11 ): 3284-6.
-
3Mohnike KL, Kluba U , Mittler U , et al . Serum levels of insulin - like growth factor-Ⅰ, -Ⅱ and insulin-like factor binding protein-2 and -3 in children with acute lymphoblastic leukemia[J]. Eur J Pediar, 1996, 155(2) :81-6.
-
4Wu HK, Weksberg R, Minden MD, et al. Loss of imprinting of human insulin-like growth factor Ⅱ gene, IGF2, in acute myeloid leukemia[J].Biochem Biophys Res Commun, 1997,231 (2) :466-72.
-
5Hattori H , Matsuzaki A , Suminoe A , et al . Genomic imprinting of insulin-like growth factor-Ⅱ in infant leukemia and childhood neuroblastoma[ J]. Cancer,2000, 88(10): 2372-7.
-
6Barrios V, Buno M, Pozo J, et al. Insulin-like growth factor-binding protein-2 levels in pediatric patients with growth hormone deficiency,eating disorders and acute lymphoblastic leukemia[ J]. Horm Res, 2000,53(5) :221-7.
-
7Wex H, Vorwerk P, Mohnike K, et al. Elevated serum levels of IGFBP2 found in children suffering from acute leukemia is accompanied by the occurrence of IGFBP-2 mRNA in the tumor clone[J]. Br J Cancer, 1998,78(4) :515-20.
-
8Muller HL, Oh Y, Lehmbecher T, et al. Insulin-like growth factor-binding protein-2 concentrations in cerebrospinal fluid and serum of children with malignant solid tumors or acute leukemia [ J ]. J Clin Endocrinol Metab,1994,79(2) :428-34.
-
9Petridou E, Skalkidou A, Dessypris N, et al. Insulin-like growth factor binding protein-3 predicts survival from acute childhood leukemia [ J ].Oncology,2001,60(3) :252-7.
-
10Brennan BM, Gill M, Pennells L, et al.Insulin-like growth factor I, IGF binding protein 3, and IGFBP protease activity: relation to anthropometric indices in solid tumors or leukemia[J] .Arch Dis Child,1999,80(3):226-30.
-
1刘晓芬,管丽华,陈瑛.婴幼儿肺炎患儿血清IGFⅡ测定的结果分析[J].放射免疫学杂志,2004,17(2):124-125. 被引量：5
-
2周湘,董峰,庞宁.肾病综合征和慢性肾功能衰竭儿童的胰岛素样生长因子及其结合蛋白的改变[J].中华儿科杂志,2001,39(1):52-53. 被引量：1
-
3谢火华,伍海洲,陈志云.儿童肺炎支原体肺炎112例分析[J].吉林医学,2011,32(17):3526-3527.
-
4高锦萍,赵青萍,缪敏.高热惊厥患儿免疫球蛋白的变化[J].苏州大学学报（医学版）,2006,26(6):1089-1089. 被引量：15
-
5钱耀琴,范洲际,查健忠,李冰冰,王平,陈钧,刘国明.小儿肺炎尿视黄醇结合蛋白测定的临床意义初探[J].上海医学,1996,19(9):528-529.
-
6史群.左旋咪唑对儿童反复呼吸道感染的预防[J].上海预防医学,1998,10(7):325-326.
-
7于晶晶.匹多莫德联合葡萄糖酸锌治疗儿童反复呼吸道感染的疗效及其对血清免疫球蛋白影响[J].中国基层医药,2013,20(18):2827-2828. 被引量：5
-
8廖红梅,杨赛,唐静文.化脓性脑膜炎患儿脑脊液CRF及IGF－Ⅱ水平变化的意义[J].医学临床研究,2011,28(8):1501-1503.
-
9梁立阳,杜敏联,李燕虹,苏喆.单纯性肥胖儿童血清胰岛素、胰岛素样生长因子-1及其结合蛋白3与生长的关系[J].中山大学学报（医学科学版）,2004,25(B06):131-133. 被引量：4
-
10潘玉娟,林荣军,孙秀芳.长期吸入糖皮质激素对支气管哮喘儿童生长激素-胰岛素样生长因子系统的影响[J].山东医药,2005,45(2):20-21. 被引量：4
