SARS患者康复期生活质量调查

Assessment of Health-related Quality of Life in Cured SARS Patients

摘要目的评估严重急性呼吸综合征(severeacuterespiratorysyndrome,SARS)患者康复期的生活质量。方法对2003年4月至2003年6月出院的119例SARS康复期患者进行生活质量调查,其中男性64例,女性55例,平均年龄(34.1±11.4)岁,平均出院时间(28.0±12.8)d。选择StGeorge's呼吸问卷(StGeorge'srespiratoryquestionnaire,SGRQ)作为生活质量调查表,其中72例患者同时行肺功能检查。结果119例SARS康复期患者SGRQ症状、活动和影响以及总分的平均分轻度增高,72例肺功能检查提示34例患者肺一氧化碳弥散量(diffusecapacityofthelungforcarbonmonoxide,DLCO)和16例患者肺一氧化碳弥散常数(diffusecapacityofthelungforcarbonmonoxide/alveolarventilation,DLCO/VA)轻度下降;多元线性分析显示,SGRQ活动、影响和总分的变化均与DLCO占预计值的百分比(DLCO/pre,DLCO%)存在负线性回归关系(r=0.47～0.54,P<0.001),症状评分的变化与肺总量占预计值百分比(totallungcapacity/pre,TLC%)和DLCO/VA占预计值百分比(DLCO/VA%)呈负线性回归关系(r=0.54,P<0.001);SARS康复期患者的年龄和性别因素对SGRQ各分值影响显著,其中大于30岁的女性对生活质量影响较大,而出院时间只对SGRQ分值中症状分数有影响。结论SGRQ可以有效。

To assess the quality of life in cured patients with severe acute respiratory syndrome (SARS).Methods One hundred and nineteen SARS outpatients,including64men and55women,with mean age (34.1±11.4)years and average days of discharge from hospital (28.0±12.8)days,were assessed by the St George' s respiratory questionnaire(SGRQ),and72patients with spirometry test.Results The patients had a moderately degree physiological impairment and increased SGRQ score.Scores of all four part of SGRQ correlated significantly with diffuse capacity of the lung for carbon monoxide/pre(DL CO %).The correlation coefficients between the activation,impaction,total score,and diffuse capacity of the lung for carbon monoxide/alveolar ventilation/pre(DL CO /V A %)were resembled(r=0.47～0.54,P<0.01).There was a significant relationship between the score of SGRQ and patients age,and gender.The time leaving hospital only had a significant relationship with the symptom score of SGRQ.Conclusions SGRQ is a sensitive tool for assessing quality of life in cured SARS patients.The cured SARS patient s' quality of life decrease moderately.