心脏术后使用呼吸机患者应用得普利麻和咪唑安定镇静效果的比较

Effect of Diprivan and Midazolam on Patients with Heart Operation Using Mechanical Ventilation

目的 观察得普利麻和咪唑安定对心脏术后呼吸机治疗病人的镇静效果。方法 选择ICU心脏术后行呼吸机治疗的病人40例,随机分为两组,得普利麻组21例,咪唑安定组19例,用微量注射泵持续注射用药,根据Ramsay氏分级标准调整用量,并记录用药量及用药前后、苏醒时的心率、血压、脉搏血氧饱和度和停药后苏醒时间,停药后再入睡和恶心发生情况。结果 两组病人随镇静程度的加深而用药量增加,但呼吸循环无明显抑制。得普利麻组苏醒时间(24±9)min较咪唑安定组苏醒时间(54±16)min为短,且苏醒后再入睡及出现恶心的病人明显减少(P<0.05)。结论 得普利麻和咪唑安定都能达到心脏术后行呼吸机治疗病人所需的镇静要求。得普利麻苏醒快,且苏醒后再入睡和恶心的发生明显少于咪唑安定。

Objective To observe effect of diprivan and midazolam used in mechanically ventilating after heart operation. Methods Forty patiens with mechanical ventilation after heart operation were randomly divided into two groups. The patients in diprivati group were infused continuously with a pump thereafter. The dosage infused was adjusted according to Ramsay classification standard. The dosage, heart rate,blood pressure,arterial oxygen .saturation before and after using the drugs and recovery time were recorded. The recovery time after stopping infusion of the drugs as well as re-sleep and emesis were also recorded. Results The dosage of the two groups increased with the increase of sedation degree. The respiratory and circulation parameters were stable. The recovery lime of the diprivan group(24±9)min was shorter than that of the midazolam group(54 ± 16)min. The number of patients sleeping again after recovery and emesis decreased obviously in the diprivan group (P<0. 02). Conclusion Both diprivan and midazolam can reach the goal of sedation needed for heart operation patients. Diprivan can lead to faster recovery after stopping the drug. The incidence of re- sleep after recovery and emesis is less when diprivan is used for heart operation patient's sedation.