甲泼尼龙、丙种球蛋白联合冲击治疗多发性硬化14例疗效分析

Effect of High-doses of Intravenous Methylprednisolone Therapy Associated with Gamma Globulin in 14 Multiple Sclerosis Cases

目的 分析大剂量甲泼尼龙联合丙种球蛋白冲击治疗多发性硬化 ( MS)的临床疗效。方法 对 1 994—2 0 0 2年采用大剂量甲泼尼龙、丙种球蛋白联合冲击治疗的 1 4例复发 -缓解型 MS患者进行回顾性分析。应用SPSS1 0 .0 ,进行两独立样本的 t检验。结果 治疗组见效时间、缓解时间、平均住院天数分别为 ( 4 .0± 1 .6)、( 2 1 .2± 3 .2 )、( 2 5 .0± 5 .9) d,均较对照组短 ( P <0 .0 5 )。结论 对于复发 -缓解型 MS,大剂量甲泼尼龙、丙种球蛋白联合冲击治疗可取得较好的疗效。

Objective To analyze retrospectively the therapeutic efficacy of 14 cases of multiple sclerosis (MS), by high doses of intravenous methylprednisolone associated with gamma globulin.Methods 14 cases of relapsing-remitting MS were carried out with two-independent-samples t test by SPSS 10.0 for windows. Results For the treatment group, coming effective time:(4.0±1.6) days(P<0.05); remitting time: (21.2±3.2) days(P<0.05); admission time: (25.0±5.9) days(P< 0.05).Conclusions For relapsing-remitting type, therapeutic efficacy of the treatment group is superior to the control group.