运动及神经内分泌对巨噬细胞功能的调节

Exercise and Neuroendocrine Modulation of Macrophage Function

像所有的免疫细胞那样 ,巨噬细胞不能仅仅被看成是独立的细胞个体 ,而是一个复杂的以不同方式引起宿主免疫应答的细胞和组织网络中的一部分。巨噬细胞是重要的初级效应细胞 ,而且容易受其它细胞 (包括T和B淋巴细胞 )和由交感神经系统 (SNS)产生的激素以及下丘脑—垂体—肾上腺皮质 (HPA)轴调节。实际上 ,包括运动在内的应激很有可能通过激活SNS ,HPA轴或者影响其它细胞和组织进行对巨噬细胞功能的调节。以下将讨论神经内分泌因素对由运动引起的巨噬细胞功能变化的调节作用。

Like all immune cells, Mφ's cannot simply be views as individual cells, but as part of complex network of cells and tissues that communicate in many different ways in an attempt to elicit an appropriate host response to immune and other challenges. Mφ's are important initial effector cells and are highly regulated by other cells(including T and B lymphocytes)and hormones produced by the sympathetic nervous system(SNS) and hypothalamic pitutary adrenal (HPA) axis. Indeed, it may well be that stressors, including exercise , exert their regulatory influence over these cells by activating the SNS, HPA axis ,or by influencing other tissued or cells. With this in mind, the overall objective of this review is to introduce and provide current information regarding the role of neuroendocrine factors in mediating exercise induced changes in macrophage(Mφ) function.