Vitamin E对大运动量训练后大鼠心血管系统调节肽分泌的影响

The Effect of Vitamin E on the Secretion of Regulating Peptides in Cardiovascular System after Overload Training in Rats

为了研究Vitamin E对大运动量训练后机体心血管系统神经调节肽分泌的影响,本文通过对大鼠进行为期8周的不同负荷的游泳训练,并给大运动量训练后的大鼠补充Vitamin E,测定血浆神经肽Y（NPY）和降钙素基因相关肽（CGHP）的含量。结果发现:①经过8周的游泳训练后,2h训练组血浆NPY含量显著高于对照组和1h训练组,血浆CGRP含量显著低于对照组,NPY/CGRP显著高于对照组和1h训练组。而1h训练组NPY含量显著低于对照组,血浆CGRP含量和NPY/CGRP与对照组相比,有下降趋势,但无显著性差异。从而说明,适当的运动训练可降低机体交感神经的兴奋性,抑制NPY的分泌。这对轻度高血压病人和正常人的血压有良好的影响;而长期大负荷的运动训练可促进机体NPY的分泌和抑制CGRP的分泌,导致NPY和CGRP的分泌失调,这可能是运动性高血压和运动性心肌损伤发生的病理生理机制。动态观察血浆NPY和CGRP的含量对于在运动过程中对心血管系统进行医务监督、预防过度训练的发生具有一定的指导意义。②Vitamin E训练组血浆NPY含量显著低于2h训练组,与对照组相比无显著差异;血浆CGRP含量显著高于2h训练组和1h训练组,与对照组相比有上升趋势,但无显著差异;NPY/CGRP显著低于2h训练组,与1h训练组和对照组相比无显著差异。所以Vitamin E可抑制大运动量?

The purpose of the research was to explore the effect of vitamin E on the secretion of regulating peptides in cardiovascular system in rats after overload training. SD rats were divided into 4 groups at random. The control group (n=9), which were not trained. The 1 hour training group (n =10) and the 2 hours training group (n=8), which were trained for 1 hour and 2 hours every time respectively, and the vitamin E group (n=9), which were trained for 2 hours and the vitamin E was replenished after training every time. After 8 weeks' swimming training, the plasma neuropeptide Y (NFY) and calcitonin gene- related peptide (CGRP) concentrations were tested by RIA. Results:① after 8 weeks' swimming training, the plasma CGRP content in 2-hr training group was lower than that in control group and the NPY content and NPY/CGRP were higher than those both in 1 - hr training group and in control group significantly. Compared with the control group, the plasma NPY content in 1 - hr training group decreased noticeably, and the plasma CGRP content and NPY/CGRP had a decreasing tendency, but there were no significant difference. This indicated that proper exercise training could reduce the sympathetic activity and restrain the secretion of NPY. Therefore properexercise training had good - influence on the drop of blood pressure in normoteasives and mildly hypertensives. However, the long term of heavy load training could promote the NPY secretion and restrain the secretion of CGRP, which caused the secretive imbalance of NPY and CGRP. It may be the pathophysiological mechanism for hypertension and myocardial ischemia during exercise. Dynamic observation of plasma NPY and CGRP concentration had some guiding significance to the medical supervisor of cardiovascular system and prevention of overload training. ② In the vitamin E group, the plasma NPY content was lower than that in 2-hr training group, and CGRP concentration was higher than that in 2 - hr training group or in 1 - hr training group significantly. There were no significant difference between the vitamin E group and the control group. NPY/CGRP in Vitamin E group was lower than that in 2 - hr training group noticeably, compared with the 1 - hr training group and the control group, there was no significant difference. It indicated that vitamin E might have some regulative effect on the secretion of regulating peptides in cardiovascular system. Replenishing vitamin E after heavy load training might have important effect on maintaining the cardiovascular function and e-liminating exercise fatigue promptly and preventing the occurrence of exercise disease.