心肌缺血/再灌注反应规律性的探讨

A Discussion of Regularity in Myocardial Ischemia/Reperfusion Reaction

本文应用镧电子示踪技术和焦锑酸分子探针技术及体视学定量方法,观察了心肌缺血不同时间再灌注后细胞膜系和线粒体镧(La^(3+))、钙(Ca^(2+))示踪所提示的线粒体的功能以及超微结构变化等特点。结果表明,心肌缺血/再灌注反应具有一定规律性,即反应初期—反应极期—反应表竭期。缺血40min到60min再灌注是可逆性与不可逆性再灌注损伤的临界点。

The regularity in myocardial ischemia/reperfusion reaction was studied by by using Lanthanum tracer and K-pyroantimonate probe technique. The resuults showed that mitochondrial La and Ca granules volume density increased significantly with the development of ischemia or reperfusion. Especially during reperfusion after 40 min ischemia, a lot of La and Ca granules were entered into mitochondrial, but during reperfusion after 60 min ischemia, La, Ca granules in mitochondria decreased significantly compared with that during reperfusion after 40 min ischemia. It suggested that the reaction of ischemia/reperfusion had certain regularity, that is, reaction stage-extreme stage of reaction-falling stage of reaction.