甘利欣对抗结核药物致肝损害疗效观察

Observing clinical effect of glycyrrhizin in treating liver injury resulted from antituberculosis drugs

目的 探讨甘利欣对抗结核药物致肝损害的治疗效果。方法 将 98例抗结核药物所致的肝损害患者随机分为两组 ,对照组 5 0例 ,停用抗结核药 ,改用基础治疗 (肝泰乐、肌苷、维生素B) ;治疗组 48例 ,不停用抗结核药 ,在对照组治疗基础上加用甘利欣进行保肝治疗 ;观察两组治疗前后临床症状和肝功能的变化情况。结果 治疗后两组患者临床症状及肝功能各项指标均有不同程度改善 (P <0 .0 1) ,且治疗组明显优于对照组 (P<0 .0 5或 <0 .0 1) ,治疗组总有效率为 89.6% ,高于对照组的 74.0 % (P<0 .0 5 )。

Objective To explore treatment effects of glycyrrhizin in treating liver injury resulting from antitubercular drugs. Methods 98 patients with such liver injury were randomly divided into two groups. There were 50 cases in control group, which stopped to use antitubercular drugs and adopted basic treatment (Glucurone, Inosine, Vitamine B), and other 48 cases were in treatment group, which treated with glycyrrhizin in addition to basic treatment, without stopping antitubercular drugs. Then observe the changes of the clinical symptoms and liver functions(ALT、AST、TBil) before and after the treatments. Results After treatments the clinical symptoms and liver functions of these patients were ameliorated in different degrees (P<0.01). Among them the amelioration of treatment group was significantly better than control group(P<0.05～0.01), and the total clinical effective rate in the treatment group (89.6%) was significantly higher than that in control group (74.0%). Conclusion Glycyrrhizin has markedly effects in treating liver injury resulting from antituberculosis drugs.