摘要
目的 探讨慢性肾衰患者 (CRF)的血管性血友病因子抗原 (vWF :Ag)和组织型纤溶酶原激活物 (t PA)的变化。 方法 收集慢性肾衰患者血清 3 8份 (观察组 ) ,健康体检血清 3 8份 (对照组 ) ,用固相酶联免疫吸附法检测血清中vWF :Ag和t PA并比较其结果。结果 观察组的vWF :Ag浓度较对照组显著升高 (P <0 .0 1) ,而t PA显著降低 (P <0 .0 1)。结论 vWF :Ag和t PA都在内皮细胞内合成并释放入血 ,慢性肾衰患者 (CRF)中两者均异常 ,表明血管内皮损伤是慢性肾衰患者 (CRF)
Objective To explore the change of antigen level of von Willebrand Factor (vWF:Ag) and tissue plasminogen activator in old people with CRF and in the controls groups.Methods 38 cases of CRFand 38 cases in the control group all underwent measuring vWF:Ag and t PA by ELISA, and the results were campared . Results The level of vWF:Ag were significantly increased (P<0.05), and the level of t PA were decreased (P<0.05) in CRF. Conclusion The results showed that the injury of vascular endothelium was an important element of the prethrombotic state of CRF in old people.
出处
《右江医学》
2004年第4期312-313,共2页
Chinese Youjiang Medical Journal