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慢性肾衰血友病因子抗原和纤溶酶原激活物变化的研究 被引量:1

The Study to The Level of vWF:Ag and t-PA in CRF
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摘要 目的 探讨慢性肾衰患者 (CRF)的血管性血友病因子抗原 (vWF :Ag)和组织型纤溶酶原激活物 (t PA)的变化。 方法 收集慢性肾衰患者血清 3 8份 (观察组 ) ,健康体检血清 3 8份 (对照组 ) ,用固相酶联免疫吸附法检测血清中vWF :Ag和t PA并比较其结果。结果 观察组的vWF :Ag浓度较对照组显著升高 (P <0 .0 1) ,而t PA显著降低 (P <0 .0 1)。结论 vWF :Ag和t PA都在内皮细胞内合成并释放入血 ,慢性肾衰患者 (CRF)中两者均异常 ,表明血管内皮损伤是慢性肾衰患者 (CRF) Objective To explore the change of antigen level of von Willebrand Factor (vWF:Ag) and tissue plasminogen activator in old people with CRF and in the controls groups.Methods 38 cases of CRFand 38 cases in the control group all underwent measuring vWF:Ag and t PA by ELISA, and the results were campared . Results The level of vWF:Ag were significantly increased (P<0.05), and the level of t PA were decreased (P<0.05) in CRF. Conclusion The results showed that the injury of vascular endothelium was an important element of the prethrombotic state of CRF in old people.
作者 孙奉劼
出处 《右江医学》 2004年第4期312-313,共2页 Chinese Youjiang Medical Journal
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参考文献1

  • 1[3]Loscalzo J, Braunwald E. Tissue plasminogen activator[J]. N Eng J Med, 1988,319 : 925-931.

同被引文献6

  • 1Stam F,van Guldener C,Schalkwijk CG,et al.Impaired renal function is associated with markers of endothelial dysfunction and increased inflammatory activity[J].Nephrology Dialysis Transplantation,2003,18(5):892-898.
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  • 4Dejanov P,Polenakovic M,Oncevski A,et al.The role of the von Willebrand factor in renal diseases and haemodialysis patients[J].Prilozi,2004,25(1-2):5-15.
  • 5Stam F,van Guldener C,Becker A,et al.Endothelial dysfunction contributes to renal function-associated cardiovascular mortality in a population with mild renal insufficiency:the Hoorn study[J].J Am Soc Nephrol,2006,17(2):537-45.
  • 6吴方,王学锋,曾晓颖,何清,璩斌,焦洁茹,黄霞萍,王鸿利.高凝状态患者止凝血分子标志物的检测及其临床意义[J].上海医学检验杂志,2000,15(3):180-182. 被引量:20

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