甘氨酸受体与全身麻醉药
Glycine Receptor and General Anesthetics
摘要
甘氨酸受体是一种重要的抑制性氨基酸受体 ,主要参与脑干及脊髓对运动及感觉的调节。近年研究发现多种全身麻醉药也可作用于甘氨酸受体。现就甘氨酸受体与全麻药的关系作一综述。
出处
《国外医学(麻醉学与复苏分册)》
2004年第4期216-219,共4页
Foreign Medical Sciences(Anesthesilolgy and Resuscitation)
参考文献18
-
1Pistis M, Belelli D, et al. The interaction of general anaesthetics with recombinant GABAA and glycine receptors expressed in Xenopus laevis oocytes: a comparative study. Br J Pharmacol, 1997,122 ( 8 ): 1707-1719.
-
2Li H, Kang JF, et al. Serotonin potentiation of glycine-activated whole-cell currents in the superficial laminae neurons of the rat spinal dorsal horn is mediated by protein kinase C. Brain Res Bu11,2002,58(6) :593-600.
-
3Yamauchi M, Sekiyama H, et al. Halothane suppression of spinal sensory neuronal responses to noxious peripheral stimuli is mediated, in part, by both GABA (A) and glycine receptor systems. Anesthesiology, 2002, 97(2) :412-417.
-
4Johnson JW, Ascher P. Glycine potentiates the NMDA response in cultured mouse brain neurons. Nature, 1987,325(5) :529-531.
-
5Mascia MP, Mihic SJ, et al. Actions on strychnine-sensitive Glycine Receptors. Mol Pharmacol, 1996,50(2) :402-406.
-
6Mascia MP, Wick MJ,et al. Enhancementof glycine receptor function by ethanol:role of phosphorylation. Br J Pharmacol,1998,125(2):263-270.
-
7Quinlan JJ, Ferguson C. Mice with glycine receptor subunit mutations are both sensitive and resistant to volatile anesthetics. Anesth Analg, 2002,95(3) :578-582.
-
8Dong XP,Xu TL. The actions of propofol on gamma-aminobutyric acid-A and glycine receptors in acutely dissociated spinal dorsal horn neurons of the rat. Anesth Analg,2002,95(4) :907-914.
-
9Lu H, Xu TL. The general anesthetic pentobarbital slows desensitization and deactivation of the glycine receptor in the rat spinal dorsal horn neurons. J Biol Chem,2002,277(44) :41369-41378.
-
10Bansinath M, Shukla VK, et al. Propofol modulates the effects of chemoconvulsants acting at GABAergic, glycinergic, and glutamate receptor subtypes. Anesthesiology, 1995,83 (4): 809-815.
-
1房云峰,杨光中.兴奋性氨基酸受体拮抗剂研究的新进展[J].中国药物化学杂志,1995,5(1):65-72.
-
2卢步峰,鲁友明,黄森.兴奋性氨基酸受体拮抗剂对大鼠缺血海马磷脂酰肌醇代谢的影响[J].中国药理学与毒理学杂志,1994,8(2):155-156. 被引量:1
-
3周玉娟,周玉勋,赵学增.抗癫闲药物及其作用机制进展[J].医学研究与教育,1998,25(4):28-29.
-
4神经系统药物[J].国外科技资料目录(医药卫生),1998(2):192-193.
-
5薛改,侯艳宁,于洋,吴红海,张文.孕酮对大鼠大脑皮质神经元氨基酸受体亚单位GBR1和NR2B表达的影响[J].中国医院药学杂志,2011,31(21):1762-1765.
-
6茆庆洪.全麻药对GABA_A受体和甘氨酸受体的作用[J].国外医学(麻醉学与复苏分册),2002,23(1):51-53.