子宫内膜异位症对体外受精-胚胎移植的影响

Effect of endometriosis on in vitro fertilization and embryo transfer

目的 探讨子宫内膜异位症 (内异症 )对体外受精 -胚胎移植 (Invitrofertilization -embryotransfer,IVF -ET)的影响。方法 对 2 0 0 1年 1月～ 2 0 0 3年 1 0月 86例内异症合并不育患者超促排卵、体外受精和胚胎移植结局等进行回顾性分析 (共 94个周期 ) ;同期 2 0 0例输卵管因素不育患者作为对照组。结果 内异症组促性腺激素需要量显著高于对照组 (P <0 0 1 )。内异症组的获卵数、受精率、优质胚胎数显著低于对照组 (P<0 0 5 ) ;裂率比较 ,差异无显著性 ;内异症组的胚胎着床率 (1 4 2 1 % )、临床妊娠率 (2 9 5 5 % ) ,低于对照组(1 9 5 2 % ,38 2 6 % ) ,差异无统计学意义。结论 内异症影响卵巢对促超排卵的反应 ,影响卵母细胞的受精。

Objective To investigate the IVF outcome for patients with endometriosis.Methods Eighty-six patients with endometriosis underwent 94cycles of IVF-ET.The control group with tubal-factor infertility consisted of 200 cycles in 200 patients.These groups were retrospectively analyzed regarding COH,embryo development,implantation,and pregnancy outcome.Results The requirement of gonadotropin significantly higher( P <0 01),the number of oocytes retrieved significantly smaller,the fertilization rate significantly lower( P <0 05) in women with endometriosis compared with controls.There was no significant difference in implantation rate,pregnancy rate.Conclusions Women with endometriosis presented a poor ovarian response to controlled ovarian hyperstimulation,a significantly lower fertilization rate and decreased tendency of implantation and pregnancy rate compared to the women with tubal factors.