大剂量复方丹参联合苦参素及自血光量子辐射疗法治疗肝纤维化临床研究

The clinical research of autoblood ultroviolet radiation therapy combined with high-dose FuFang Danshen injection and Marine for the treatment of hepatic fibrosis

目的 探讨大剂量复方丹参联合黄芪、苦参素及自血光量子辐射疗法综合治疗肝纤维化的效果。方法 1 1 0例肝纤维化患者随机分为 A、B、C组 ,A组 36例用卡托普利及中药 (复方丹参、黄芪注射液 )治疗 ;B组 4 6例用卡托普利及中药联合自血光量子辐射疗法 ;C组 2 8例用大剂量复方丹参联合黄芪、苦参素及自血光量子辐射疗法 ;观察治疗前后血清透明质酸 (HA)和乙肝病毒标志及肝功能变化。结果 A、B、C组治疗 1月后 HA降幅分别为 (37.72± 5 4 .4 5 ) % ,(4 9.5 3± 35 .2 8) % ,(5 9.82± 1 7.4 9) % ;按 HA较治疗前下降 4 0 %以上为有效 ,3组总有效率分别 6 1 .1 %、76 .1 %、85 .7% ,χ2 =5 8,P<0 .0 0 1 (各组疗效有显著差异 )。结论 大剂量复方丹参联合黄芪、苦参素等与自血光量子辐射疗法可增加重度肝纤维化的治疗效果 。

Objective To observe the therapeutic effect of autoblood ultroviolet radiation therapy(AURT) combined with high dose FuFang Danshen injection , Huangqi injection and Marine on hepatic fibrosis(HF). Methods 110 cases of HF were randomly allocated to Group A, Group B and Group C. Group A( n =36) was treated with captopril and traditional Chinese medicine (FuFang Danshen and Huangqi injection,FDHI). Group B ( n =46) was treated with AURT combined with captopril and FDHI. Group C ( n =28) was treated with AURT combined with high dose FuFang Danshen injection, Huangqi injection and Marine. The changes of symptoms and signs, serum hyaluronate(HA), hepatitis B virus markers and the hepatic function were observed before and after treatment. Results The declined extent of HA in three groups were (37.72±54.45)%,(49.53±35.28)%,(59.82± 17.49 )% respctively; when the declined extent of HA >40%, the total effective rate in three groups were 61.1%,76.1%,85.7% respectively,χ 2=58, P <0.001. Conclusions AURT combined with high dose FuFang Danshen injection, Huangqi injection and Marine can increase the therapeutic effect of routine therapy on severe HF, and is worth widely research.