急性有机磷农药中毒心肌损伤检测指标的探讨

DETECTION OF MYOCARDIAL LESION IN PATIENTS WITH ACUTE ORGANOPHOSPHORUS PESTICIDE POISONING

目的:探讨检测急性有机磷农药中毒(AOPP)患者心肌损伤的高敏感性指标。方法:分别测定53例AOPP患者及20例正常对照组的心肌肌钙蛋白Ⅰ(cTnI)、肌酸磷酸激酶(CK)、肌酸磷酸激酶同功酶(CK-MB),同时作心电图检查。结果:中度、重度AOPP组CK、CK-MB均高于正常对照组,差异有统计学意义(P<0.05或P<0.01);高度中毒组心肌cTnI阳性检出率高于CK、CK-MB和心电图,差异有统计学意义(P<0.05或P<0.01)。结论:cTnI有助于更好地检测AOPP引起的心肌损伤。

Objective: To find a better index for detecting myocardial lesion in patients with acute organophosphorus pesticide poisoning(AOPP). Method: Cardiac troponin I(cTnl) ,creatine kinase(CK) ,creatine kinase-MB isoenzyme(CK-MB) and electrocardiagram (ECG) were determined in 53 patients with AOPP and 20 healthy controls. Results: In moderate and severe AOPP patients, the levels of CK,CK-MB were significantly higher than those in healthy control(respectively, P< 0.05 or P< 0.01). In severe patients,cTnl positive detection rate was significantly higher than that of CK,CK-MB and ECG(F<0.05 or P< 0.01). Conclusion:cTnI is a better index to detect myocardial leion in AOPP.