摘要
目的 研究氯沙坦是否可抑制OxLDL诱导的血管内皮细胞凋亡。 方法应用大鼠模型,LDL体内诱导血管内皮细胞凋亡,氯沙坦进行干预,观察其对LDL诱导血管内皮细胞凋亡的影响。TUNEL法检测凋亡细胞。 结果 LDL组和正常对照组比较凋亡血管内皮细胞显著增加;氯沙坦组和LDL组比较凋亡细胞显著减少。 结论氯沙坦可抑制LDL诱导的血管内皮细胞凋亡。
Objective To investigate the influence of Losartan on LDL inducing apoptosis of arterial endothelial celis in rats. Methods The rats modei of arterial endothelial celis apoptosis was established by intravenous injecting LDL to induce apoptosis. Losartan was used to intervene LDL group. A normai group was also established as the control.In the three groups,apoptotic endothelial celis were detected by TUNEL method. Results Comparing with normai group, the number of apoptosis celis in LDL group was increased obviously( 10.02 ± 2.62 vs 89.73 ± 17.86, P < 0.01),and the effect was inhibited significantly after the in-tervention of Losartan(23.61 ± 9.03 vs 89.73 ± 17.86, P < 0.01). Conclusion Losartan could inhibit the apoptosis of arterial endothelial celis in rats being caused by LDL.
出处
《实用心脑肺血管病杂志》
2004年第5期257-259,共3页
Practical Journal of Cardiac Cerebral Pneumal and Vascular Disease
基金
湖北省科技攻关计划项目(No.2001AA307B03)
