早期血液滤过治疗重症急性胰腺炎的探讨

Study on early hemofiltration for treating severe acute pancreatitis

目的 :探讨早期血液滤过治疗重症急性胰腺炎的疗效。方法 :20例急性重症胰腺炎病人随机分为血液滤过组 (HF)和非血液滤过组 (NHF) ,每组10例。观察两组间腹痛、腹胀缓解时间及APACHEⅡ评分。结果 :HF组和NFH组腹痛、腹胀缓解时间分别为 (10.0±5.8)小时及 (80.0±46.6)小时和 (21.8±7.6)小时及 (78.6±38.4)小时 ,两组比较 ,差异有显著性P<0.05 ,HF组的A PACHEⅡ评分在入院第一天显著下降 ,第四天起显著低于NHF组 ,P<0.05。结论 :重症急性胰腺炎病人行早期血液滤过治疗能有效缓解临床症状 ,改善重症急性胰腺炎的预后。

Objective:To investigate the clinical effect of early hemofiltration for treating severe acute pancreatitis(SAP).Methods:20paˉtients with SAP were divided into hemofiltration(HF)group and non-hemofiltration(NHF)group at random,with10cases in each group.The time of remission of abdominal pain and abdominal distension and the APACHEⅡscore were recorded.Results:The time of remission of abdominal pain and abdominal distension in HF group and NHF group was(10.5±5.8)hours and(80.0±46.6)hours vs(21.8±7.6)hours and(78.6±38.4)hours respectively,with a marked difference between two groups(P<0.05).The APACHEⅡscore in HF group declined significantly at the first day after admission.which was significantly lower from the fourth day than that in the NHF group(P<0.05).Conclusion:Early hemofiltration for treating severe acute pancreatitis can effectively ameliorate the clinical symptoms and improves the prognosis of SAP.