美托洛尔、比索洛尔治疗右室流出道特发性室性早搏46例分析

Analysis of 46 cases of idiopathic ventricular premature beat origin from right ventricular outflow tract by metoprolol or bisoprolol treatment

目的 :了解右室流出道特发性室性早搏心电图特征及治疗。方法 :心电图Ⅱ、Ⅲ、AVF导联呈高大“R”波 ,多数无需药物治疗 ,对心率快 ,运动后或精神紧张等导致室早增多并伴有症状者 ,用小剂量 β 受体阻滞剂治疗。结果 :46例患者 ,其中美托洛尔组21例 ,显效8例 ,有效7例 ,无效6例 ;比索洛尔组25例 ,显效12例 ,有效9例 ,无效4例。结论 :比索洛尔 (康可 )总有效率比美托洛尔 (倍他乐克 )高 (84 00 %vs71.43 %,P<0 05) ,可能与前者是超高选择性 β1 肾上腺素能受体阻滞有关。

Objective:To understand the character and treatment of the electrocardiogram(ECG)of idiopathic ventricular premature beat oˉrigin from right ventricular outflowtract.Methods:The character of the ECG was that the wave of R was wide and high in the lead ofⅡ、Ⅲand AVF.Most of the ventricular premature beat needed not medicine treatment,but it showed obvious effect by the treatment of lowdoseβ-receptor blocker,especially the ventricular premature beat of the patients was increase in the condition of the rapid heart rate or postexercise or psychenˉtonia.Results:46cases were observed in this group,21cases in the metoprolol group were treated by metoprolol(obviously effective8cases,efˉfective7cases,inefficiency6cases)and25cases in the bisoprolol group were treated by bisoprolol(obviously effective12cases,effective9cases,inefficiency4cases).Conclusion:The total effective rate in the bisoprolol group was higher than that in the metoprolol group(84.00%vs71.43%,P<0.05).It may be related with that the bisoprolol is a ultra selective blocker ofβ-adrenergic receptor.