Fas、FasL和Bcl-2在膀胱癌组织的表达及意义

Relationship between the expression of Fas, FasL and Bcl-2 in bladder cancer

目的 研究Fas蛋白 (CD95 /Apol 1,Fas)、Fas配体 (Fasligand ,FasL)及Bcl 2在膀胱癌组织中的表达 ,并探讨其临床意义。方法 采用免疫组化LSAB法检测 5 0例膀胱癌组织及 6例正常膀胱黏膜中Fas、FasL和Bcl 2的表达。结果 Fas、FasL及Bcl 2在膀胱癌组织中的阳性表达率分别为 5 0 %、38%、4 2 %。膀胱癌组织FasL和Bcl 2的阳性表达率明显高于正常组织 (P <0 .0 5 ) ,Fas明显低于正常组织 (P <0 .0 5 )。Fas的表达与膀胱癌病理分级、复发有关 (P <0 .0 5 ) ;FasL、Bcl 2表达与各项病理指标均无关 (P >0 .0 5 )。结论 Fas的表达降低与膀胱肿瘤的恶性化程度有关。

Objective To investigate the relationship between the expression of Fas, FasL and Bcl-2 in bladder cancer and its clinical significance. Methods Immunohistochemistry LSAB method was used to detect Fas, FasL and Bcl-2 expression in 50 bladder cancer specimens and 6 normal bladder mucosa tissues. Results Significant differences were found between bladder cancer and normal bladder mucosa tissues in the expression of Fas, FasL and Bcl-2 (P< 0.05 ). The positive expression rate of Fas, FasL and Bcl-2 was 50%, 38% and 42%. The positive expression rate of FasL and Bcl-2 in bladder cancer was significantly greater than that in normal tissues (P< 0.05 ). While that of Fas was significantly lower than in normal tissues (P< 0.05 ). Fas expression was associated with grade and recurrence (P< 0.05 ), FasL and Bcl-2 expressions were not associated with any pathological index (P>0.05). Conclusion The lower expression of Fas in bladder cancer is associated with malignancy degree. The abnormal expression of FasL and Bcl-2 is related to bladder tumorigenesis.