抗环瓜氨酸肽抗体和类风湿因子对类风湿关节炎诊断价值的研究

Study on the anti-cyclic citrullinated peptide antibodies and the rheumatoid factors in the diagnosis of rheumatoid arthritis

目的评价抗环瓜氨酸肽(ACCP)抗体与类风湿因子(RF)各亚型在类风湿关节炎(RA)诊断中的价值。方法收集108例RA患者,与38例其他疾病患者对照,用ELISA测定ACCP与RF各亚型,以美国风湿病协会(ACR)修订的RA分类标准,通过四格表计算诊断试验的特异度、敏感度,进行统计学分析。结果ACCP的特异度高于IgA鄄RF、IgM鄄RF,与IgG鄄RF相比差异无显著性,敏感度高于IgA鄄RF、IgG鄄RF,与IgM鄄RF相比差异无显著性。结论ACCP对RA有较高的诊断价值。

Objective To determine the value of the anti-cyclic citrullinated peptide antibodies(ACCP) and the rheumatoid factors (RF) subtypes in the diagnosis of the rheumatoid arthritis(RA). Methods The above-mentioned antibodies were determined in 108 RA patients and 38 non-RA controls. According to the classification standard of RA revised by American Rheumatism Associotion, the specificity and the sensitivity of ACCP, IgA-RF, IgG-RF and IgM-RF were calculated by the fourfold table. Results The specificity of ACCP was higher than that of IgA-RF and IgM-RF and without difference from that of IgG-RF. The sensitivity of ACCP was higher than that of IgA-RF and IgG-RF and without difference from that of IgM-RF. Conclusions ACCP is valuable for RA diagnosis.