16例双侧肾母细胞瘤的危险因素分析

The analysis of risk factors in bilateral nephroblastoma of 16 cases

目的 分析双侧肾母细胞瘤的危险因素。方法 用Kaplan Meier生存分析方法对我院从 196 0～ 2 0 0 2年收治的 16例双侧肾母细胞瘤进行生存时间研究。结果 是否伴发畸形、是否术前化疗、病理分型为影响双侧肾母细胞瘤生存的危险因素 ;本组病例五年生存率为 37.0 5 %。结论 伴发畸形的双侧肾母细胞瘤预后较差。术前常规化疗是提高双侧肾母细胞瘤长期生存率的重要因素。根据组织学类型和临床分期 ,严格按照NWTS 5的标准 ,以使治疗个体化 。

Objective To identify risk factors of bilateral nephroblastoma. Methods Sixteen cases of bilateral nephroblastoma were admitted and treated in this Department from 1960 to 2002. Their survival time and the related factors were studied by Kaplan Meier analysis. Results Five years survival rate was 37.05% in this series. The prognosis was poor, when there was an accompanied malformation. Routine preoperative chemotherapy was very important to the long term survival. Conclusions The associated malformation, preoperative chemotherapy and pathological characteristics of the tumors were found to be the most important risk factors that affected survival of the patients with bilateral nephroblastoma. Individualized treatment based on the histological classification and clinical staging (NWTS 5) seems also to play an important role in improving the survival time.