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一例异基因造血干细胞移植后合并非结核分支杆菌肺病——附文献复习 被引量：3

Pulmonary disease caused by nontuberculous mycobacteria after allogeneic hematopoietic stem cell transplantation——a case report and literature review
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摘要 目的　报道 1例异基因造血干细胞移植 (allo HSCT)后发生非结核分支杆菌 (NTM )肺病患者 ,经抗NTM治疗有效。方法　病例分析及文献复习。结果　 1例急性非淋巴细胞白血病患者完全缓解后行异基因造血干细胞移植 (allo HSCT) ,移植后发生NTM感染 ,经克拉霉素、卷曲霉素、左旋氧氟沙星抗NTM治疗有效。结论　allo HSCT后NTM感染比较少见 。 Objective To report a case with pulmonary disease caused by nontuberculous mycobacteria(NTM) after allogeneic hematopoietic stem cell transplantation(allo-HSCT),with a literature review. Methods Case report and literature review. Results A patient with acute non-1ymphocytic leukemia was treated by allo-HSCT. Her NTM lung disease developed after HSCT was successfully treated with a 3 antimicrobials combination of clarithromycin,levofloxacin and capreomycin for 10 months.Conclusion NTM infections are infrequent in allo-HSCT recipients and have a good clinical prognosis if correctly treated.
作者 陈波 吴德沛 孙爱宁 仇惠英 傅琤琤 唐晓文 马骁 金正明 苗瞄 何广胜 刘跃均 赵晔 吴小津 朱霞明
机构地区 苏州大学附属第一医院血液科江苏省临床免疫重点实验室
出处 《中华血液学杂志》 CAS CSCD 北大核心 2004年第8期470-472,共3页 Chinese Journal of Hematology
基金 江苏省医学重点人才基金资助项目 (RC2 0 0 2 0 3 3 ) 江苏省卫生厅重点课题资助项目 (H2 0 13 ) 江苏省社会发展基金资助项目 (BS2 0 0 2 0 12 )
关键词 异基因 造血干细胞移植 合并症 非结核分支杆菌 肺病 HSCT 不良反应 Hematopoietic stem cell transplantation,allogeneic Mycobacterium, nontuberculosis Infection
分类号 R733.7 [医药卫生—肿瘤]
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参考文献10

  • 1Roy V, Weisdorf D. Mycobacterial infections following bone marrow transplantation: a 20 year retrospective review. Bone Marrow Transplant, 1997,19: 467-470.
  • 2Kurzrock R,Zander A, Vellekoop L,et al. Mycobacterial pulmonary infections after allogeneic bone marrow transplantation.Am J Med, 1984,77:35-40.
  • 3Hoyle C, Goldman JM. Life-threatening infections occurring more than 3 months after BMT. Bone Marrow Transplant,1994,14:247-252.
  • 4Budak-Alpdogan T,Tangun Y,Kalayoglu-Besisik S, et al. The frequency of tuberculosis in adult allogeneic stem cell transplant recipients in Turkey. Biol Blood Marrow Transplant, 2000,6:370-374.
  • 5Tostch M,Schmid KW, Brommelkamp E,et al. Rapid detection of mycobacterial DNA in clinical samples by multiplex PCR. Diagn Mol Pathol, 1994,3: 260-264.
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  • 8Wallace RJ,Glassroth J,Griffith DE,et al. Diagnosis and treatment of disease caused by nontuberculous mycobacteria. Am J Respir Crit Care Med, 1997,156 :S1-25.
  • 9Gaviria JM,Garcia PJ,Garrido SM,et al. Nontuberculous mycobacterial infections in hematopoietic stem cell transplant recipients: characteristics of respiratory and catheter-related infections.Bio1 Blood Marrow Transplant, 2000,6 :361-369.
  • 10Weinstock DM,Feinstein MB,Sepkowitz KA,et al. High rates of infection and colonization by nontuberculous mycobacteria after allogeneic hematopoietic stem cell transplantation. Bone Marrow Transplant, 2003,31:1015-1021.

同被引文献14

  • 1戴自英.实用内科学(上册)[M](第9版)[M].北京:人民卫生出版社,1995.243-247.
  • 2Gaviria J M, Garcia P J, Garrido S M, et al. Nontuberculons myeobacterial infections in hernatopoietic stem cell transplant recipients: Characteristics of respiratory and catheter-related infections [J]. Biol Blood Marrow Transplant,2000,6:361-369.
  • 3Weinstock D M, Feinstein M B, Sepkowitz K A, et al. High rates of infection and colonization by nontuberculous mycobacteria after allogeneic hernatopoietic stem cell transplantation [J]. Bone Marrow Transplant, 2003,31 : 1015 - 1021.
  • 4Katoch VM. Infections due to non-tuberculous mycobacteria (NTM). Indian J Med Res,2004, 120 : 290-304.
  • 5Redaelli de zinis LO, Tironi A, Nassif N, et al. Temporal bone infection caused by atypical mycobacterium: case report and review of the literature. Otol Neurotol,2003 ,24 :843-849
  • 6Meybeck A, Fortin C, Abgrall S, et al. Spondylitis due to Mycobacterium xenopi in a human immunodeficiency virus type 1-infected patient : case report and review of the literature. J of Clin Microbiology, 2005,43 : 1465-1466.
  • 7Okano A, Shimazaki C, Ochiai N, et al. Subcutaneous infection with Mycobacterium fortuitum after allogeneic. Bone Marrow Transplant, 2001,28 : 709 -711.
  • 8Wallace RJ, Glassroch J, Griffith DE, et al. Diagnosis and treatment of disease caused by nontuberculous mycobacteria. Am J Respir Ctit care Med, 1997,156 : S1-25.
  • 9Doucette K, Fishman JA. Nontuberculous mycobacterial infection in hematopoietic stem cell and solid organ transplant recipients. Clin Infect Dis ,2004,38 : 1428-1439.
  • 10Cordonnier C, Martino R, Trabasso P, et al. Mycobacterial infection: a difficult and late diagnosis in stem cell transplant recipients. Clin Infect Dis ,2004,38 : 1229-1236.

引证文献3

中华血液学杂志
2004年 第8期

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