粒-巨噬细胞集落刺激因子在肺表面活性物质稳态调节中的作用
被引量：1
摘要
粒 巨噬细胞集落刺激因子 (GM CSF)是一种细胞生长因子 ,常用于化疗及骨髓移植后刺激造血恢复。近年通过转基因动物的研究发现 ,GM CSF或其受体基因敲除鼠并未出现造血系统紊乱 ,唯一的病理改变是肺内表面活性物质磷脂和蛋白的蓄积。该研究提示GM CSF在造血系统稳态调节中作用甚微 ,而在肺表面活性物质的代谢平衡中却起着至关重要的作用。
出处
《国外医学（呼吸系统分册）》
2004年第4期222-224,共3页
Section of Respiratory System Foreign Medical Sciences
参考文献13
-
1Kitamura T,Tanaka N,Watanabe J,et al.Idiopathic pulmonary alveolar proteinosis as an autoimmune disease with neutralizing antibody against granulocyte/macrophage colony-stimulating factor.J Exp Med,1999,190:875-880.
-
2Zsengeller ZK,Reed JA,Bachurski CJ,et al.Adenovirus-mediated granulocyte-macrophage colony-stimulating factor improves lung pathology of pulmonary alveolar proteinosis in granulocyte-macrophage colony-stimulating factor-deficient mice.Hum Gene Ther,1998,9
-
3Metcalf D.Cellular hematopoiesis in the twentieth century.Semin Hematol,1999,36:5-12.
-
4Yoshida M,Ikegami M,Reed JA ,et al.GM-CSF regulates protein and lipid catabolism by alveolar macrophages.Am J physiol Lung Cell Mol Physiol,2001,280:L379-L386.
-
5Dirksen U,Nishinakamura R,Groneck P,et al.Human pulmonary alveolar proteinosis associated with a defect in GM-CSF/IL-3/IL-5 receptor common beta chain expression.J Clin Invest,1997,100:2211-2217.
-
6Kavuru MS,Sullivan EJ,Piccin R,et al.Exogenous granulocyte-macrophage colony-stimulating factor administration for pulmonary alveolar proteinosis.Am J Respir Crit Care Med,2000,161:1143-1148.
-
7Bernhard W,Haagsman HP,Tschernig T ,et al.Conductive airway surfactant: surface-tension function,biochemical composition and possible airway origin.Am J Respir Cell Mol Biol,1997,17:41-50.
-
8Frerking I,Gunther A,Seeger W,et al.Pulmonary surfactant: functions,abnormalities and therapeutic options.Intensive Care Med,2001,27:1699-1717.
-
9Fisher JH,Sheftelyelyevich V,Ho YS,et al.Pulmonary-specific expression of SP-D corrects pulmonary lipid accumulation in SP-D gene-targeted mice.Am J Physiol Lung Cell Mol Physiol,2000,278:L365-L373.
-
10Reed JA,Ikegami M,Robb L,et al.Distinct changes in the pulmonary surfactant homeostasis in common beta-chain-and GM-CSF-deficient mice.Am J Physiol Lung Cell Mol Physiol,2000,278:L1164-L1171.
同被引文献18
-
1Fisher JH,Sheftelyelyevich V,Ho YS,et al.Pulmonary specificexpression of SP-D corrects pulmonary lipid acc-umulation SP-D gene targeted mice[J].Am J Physiol Lung Cell Mol Physiol.2000,278:365-373.
-
2Gurel O,Ikegami M,Chroneos ZC,et al.Macrophage and type Ⅱ cell catabolism of SP-A and,sarurated phosphatidy choline in mouse lungs[J].Am J Physiol Lung Cell Mol Physiol,2001,280:1266-1272.
-
3Frerking I,Gunther A,Seege W,et al.Pulmonary surfactant:functions,abnormalities and therapeutic options[J].Intensive Care Med,2001,27:1699-1717.
-
4O'Sullivan MP,Tyner JW,Holtzman MJ.Apoptosis in the airways:another balancing act in the epithelial program[J].Am J Respir Cell Mol Biol,2003,29(1):3-7.
-
5Pelaia G,Cuda G,Vatrella A,et al.Effects of transforming growth factor-beta and budesonide on mitogen activated protein kinase activation and apoptosis in airway epithelial cells[J].Am J Respir Cell Mol Biol,2003,29(1):12-18.
-
6Kasper M,Sims G,Koslowski R,et al.Increased surfactant protein D in an airway goble and Clara cells during ovalbumin induced allergic airway inflammation[J].Clin Exp Allergy,2002,32:1251-1258.
-
7Cheng G,Ueda T,Numao T,et al.Increased levels of surfactant protein A and D in bronchoalveolar lavage fluids in patients with bronchial asthma[J].Eur Respir J, 2000,16:831-835.
-
8Haczku A,Atochina EN,Tomer Y,et al.The late asthmatic response is linked with increased surface tension and reduced surfactant protein B in mice[J].Am J Physiol Lung Cell Mol Physiol,2002,283:755-765.
-
9Lewis JF,Jobe AH.Related articles,links surfactant and the adult respiratory distress syndrome[J].Am Rev Respir Dis,1993,147(1):218-233.
-
10Gunther A,Sieberit C,Schmidt R,et al.Related articles,links surfactant alterations in severe pneumonia,acute respiratory distress syndrome,and cardiogenic lung edema[J].Am J Respir Crit Care Med,1996,153(1):176-184.
-
1肖铁卉,王士雯.血管紧张素Ⅱ受体之间的相互作用及在心血管疾病中的作用[J].临床荟萃,2007,22(10):753-755.
-
2翟明,许崇安,蔡大力,吕晓毅,梁洪伟,王舒宝.粒—巨噬细胞集落刺激因子在血液病的临床应用[J].中国医科大学学报,1995,24(1):61-63.
-
3王鸿程,唐凤鸣,李万成,李艳萍.血粒-巨噬细胞集落刺激因子、嗜酸粒细胞联合检测对哮喘气道炎症的评价[J].中国呼吸与危重监护杂志,2005,4(2):95-95. 被引量：6
-
4黄献章,罗南辉,曾益华,许瑞佳.白细胞介素-6及粒-巨噬细胞集落刺激因子在急性中毒中作用的研究[J].中国急救医学,2000,20(10):592-593. 被引量：2
-
5王月州.COPD患者治疗前后血清NO、NOS和GM-CSF检测的临床意义[J].放射免疫学杂志,2011,24(6):631-633. 被引量：4
-
6张淑英,姜丽波,张雪芳,韩树林,周虹,曲延章,郭珩,王苏亮.GCS方案治疗重型再生障碍性贫血T细胞亚群的变化研究[J].中国实用内科杂志,2011,31(12):952-953.
-
7李明珍.应用粒－巨噬细胞集落刺激因子治疗老年人血液病三例[J].中华老年医学杂志,1995,14(1):50-50.
-
8李晓诗,邹正辉,虞斐,付晋翔,杨吉成,盛伟华,陈志荣,蔡苏皖.脐带血清对骨髓粒—巨噬细胞集落形成的影响[J].中国免疫学杂志,1995,11(3):182-184. 被引量：1
-
9贾志凌,杨科,梅巍,滕爱萍,何学鹏.再生障碍性贫血患者检测粒单系祖细胞的临床意义[J].中华内科杂志,1998,37(10):692-692. 被引量：1
-
10张伟,钟南山,徐军.支气管哮喘患者粒-巨噬细胞集落刺激因子mRNA表达的研究[J].中华结核和呼吸杂志,2000,23(9):534-537. 被引量：6
